CARS2 and RIPK4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CARS2	RIPK4
Description		cysteinyl-tRNA synthetase 2, mitochondrial	receptor interacting serine/threonine kinase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Cysteine-tRNA Ligase Activity ATP Binding Ligase Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Cysteinyl-tRNA Aminoacylation	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Mitochondrial tRNA aminoacylation
Drugs		Cysteine
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 26969751) Parkinson's disease ( 34064523)	Femur bone mineral density x serum urate levels interaction ( 34046847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		7 interacting genes: GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B OGT RIPK4	38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP
Entrez ID		79587	54101
HPRD ID		07763	10419
Ensembl ID		ENSG00000134905	ENSG00000183421
Uniprot IDs		B7Z7E6 Q9HA77	Q96T11 Q9H4D1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Macroautophagy Autophagosome Maturation Autophagosome Membrane Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Autophagosome Organization Autophagy Phospholipid Binding Protein-containing Complex Disassembly Vacuole Organization Cellular Response To Starvation Response To Nutrient Levels Response To Starvation GABA Receptor Binding Organelle Assembly Ubiquitin Protein Ligase Binding Beta-tubulin Binding Microtubule Binding Protein-containing Complex Organization Microtubule Cytoplasmic Vesicle Catabolic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Cellular Component Assembly Regulation Of Protein Localization To Synapse Regulation Of Proteasomal Protein Catabolic Process Regulation Of Receptor Localization To Synapse Organelle Organization Regulation Of Rac Protein Signal Transduction Cellular Response To Stress Endomembrane System Organelle Membrane Response To Stress Negative Regulation Of Proteasomal Protein Catabolic Process Cytosol Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Axoneme Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane
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