NR1H3 and FOXO3

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
HPRD (two hybrid)

		NR1H3	FOXO3
Description		nuclear receptor subfamily 1 group H member 3	forkhead box O3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Protein-containing Complex RNA Polymerase II Transcription Repressor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Chromatin DNA Binding Sterol Response Element Binding Sequence-specific DNA Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Chromatin DNA Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Lipid Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Circadian Rhythm MRNA Transcription By RNA Polymerase II Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress	Negative Regulation Of Transcription By RNA Polymerase II Ovulation From Ovarian Follicle Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Oocyte Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mitochondrial Transcription Regulation Of Translation Apoptotic Process Response To Xenobiotic Stimulus Positive Regulation Of Autophagy Positive Regulation Of Muscle Atrophy DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Response To Nutrient Levels Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis Response To Starvation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Brain Morphogenesis Canonical Wnt Signaling Pathway Response To Fatty Acid Cellular Response To Glucose Stimulus Cellular Response To Corticosterone Stimulus Cellular Response To Hypoxia Response To Dexamethasone Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of MiRNA Transcription Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus Response To Water-immersion Restraint Stress Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PPARA activates gene expression VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Mitochondrial unfolded protein response (UPRmt)
Drugs		TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Diacerein Rhein
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood glucose levels ( 31928498) Creatinine levels ( 29403010) Feeling miserable ( 29500382) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 20686565 19060910) Hypertension ( 31879980) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 27863252) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 27863252) Mood instability ( 31168069) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Triglyceride levels ( 32154731) Triglycerides ( 30275531)	Adult body size ( 32376654) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Anxiety/tension (special factor of neuroticism) ( 30867560) Appendicular lean mass ( 33097823) Blood protein levels in cardiovascular risk ( 28369058) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 28448500 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area ( 32963231) Cortical volume ( 32963231) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Insulin-like growth factors ( 21216879) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lead levels ( 26025379) Macular thickness ( 30535121) Normalized brain volume ( 19010793) Platelet distribution width ( 27863252 32888494) Poor prognosis in Crohn's disease ( 28067912) Prostate cancer ( 23535732) Pulse pressure ( 30224653) Reaction time ( 29844566) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Schizophrenia ( 28991256 30285260) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Thalamus volume ( 34006833) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		35 interacting genes: ACTN1 APP BAG3 CEP350 EDF1 FOXO3 GPANK1 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA PPARD PPARG PSMC5 RARA RXRA RXRB RXRG SIRT1 SS18L1 SUV39H1 SYT1 TMEM161A UBE2I ZXDC	27 interacting genes: AKT1 ANAPC11 BTRC CDK6 CDT1 CHUK CREBBP EP300 ERBIN ESR1 FOXG1 IKBKB MAPK1 MAPK6 MDM2 NR1H2 NR1H3 PTPA SGK1 SIRT1 SMAD2 SMAD3 SMAD4 TERT VDR YWHAG YWHAZ
Entrez ID		10062	2309
HPRD ID		07211	04061
Ensembl ID		ENSG00000025434	ENSG00000118689
Uniprot IDs		B4DXU5 B5MBY7 F1D8N1 Q13133	A0A856PRE8 O43524
PDB IDs		1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJS	2K86 2LQH 2LQI 2UZK 6MNL 7V9B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Receptor Activity Hormone-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Chromatin Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Metabolic Process Transcription Coactivator Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Retinoid X Receptor Binding Nucleoplasm RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Retinoic Acid-responsive Element Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Steroid Receptor Activity Regulation Of Programmed Cell Death Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Regulation Of Lipid Metabolic Process Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process	Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Immune Response Regulation Of Gene Expression Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Cellular Response To Nutrient Levels Regulation Of Biological Quality Regulation Of Multicellular Organismal Process Regulation Of Protein Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Immune System Process Regulation Of Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Oxygen Levels Regulation Of Intracellular Signal Transduction Response To Nutrient Levels Regulation Of Defense Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication
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