NR1H3 and CEP350

Number of citations of the paper that reports this interaction (PubMedID 15615782)
0

Data Source:
BioGRID (pull down)

		NR1H3	CEP350
Description		nuclear receptor subfamily 1 group H member 3	centrosomal protein 350
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Membrane Ciliary Basal Body Cell Projection
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Chromatin DNA Binding Sterol Response Element Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Microtubule Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Lipid Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Circadian Rhythm MRNA Transcription By RNA Polymerase II Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress	Microtubule Anchoring Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways		PPARA activates gene expression VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs		TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Diacerein Rhein
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood glucose levels ( 31928498) Creatinine levels ( 29403010) Feeling miserable ( 29500382) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 20686565 19060910) Hypertension ( 31879980) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 27863252) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 27863252) Mood instability ( 31168069) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Triglyceride levels ( 32154731) Triglycerides ( 30275531)	Anorexia nervosa ( 23568457) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Smoking initiation ( 30617275)
Interacting Genes		35 interacting genes: ACTN1 APP BAG3 CEP350 EDF1 FOXO3 GPANK1 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA PPARD PPARG PSMC5 RARA RXRA RXRB RXRG SIRT1 SS18L1 SUV39H1 SYT1 TMEM161A UBE2I ZXDC	7 interacting genes: APP APTX NR1H3 PLEKHA5 PPARA PPARD PPARG
Entrez ID		10062	9857
HPRD ID		07211	09870
Ensembl ID		ENSG00000025434	ENSG00000135837
Uniprot IDs		B4DXU5 B5MBY7 F1D8N1 Q13133	Q5T2X4 Q5VT06
PDB IDs		1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJS	2COZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Receptor Activity Hormone-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Chromatin Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Metabolic Process Transcription Coactivator Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Retinoid X Receptor Binding Nucleoplasm RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Retinoic Acid-responsive Element Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Steroid Receptor Activity Regulation Of Programmed Cell Death Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Regulation Of Lipid Metabolic Process Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process	Negative Regulation Of Cholesterol Storage Negative Regulation Of Lipid Storage Negative Regulation Of MiRNA Transcription Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Small Molecule Metabolic Process Hormone-mediated Signaling Pathway Regulation Of Lipid Storage Nuclear Receptor Activity Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Ketone Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Cellular Response To Oxygen-containing Compound Negative Regulation Of Type II Interferon-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Developmental Process Regulation Of Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Defense Response Peroxisome Proliferator Activated Receptor Signaling Pathway Fatty Acid Metabolic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Lipid Transport Nuclear Steroid Receptor Activity Regulation Of Defense Response Negative Regulation Of RNA Metabolic Process Response To Nutrient Regulation Of Protein Transport Positive Regulation Of Cholesterol Efflux Negative Regulation Of Myoblast Differentiation Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Cell Growth Sequence-specific DNA Binding Monocarboxylic Acid Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?