NR1H3 and CEP350

Number of citations of the paper that reports this interaction (PMID 15615782)
6

Data Source:
BioGRID (pull down)

		NR1H3	CEP350
Gene Name		nuclear receptor subfamily 1, group H, member 3	centrosomal protein 350kDa
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex	Nucleoplasm Cytoplasm Centrosome Spindle Membrane
	Molecular Function	DNA Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Sterol Response Element Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Protein Binding Microtubule Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Homeostasis	Microtubule Anchoring
Pathways
Drugs
Diseases
GWAS		HDL cholesterol ( 19060910 20686565) Metabolic syndrome ( 22399527)	Anorexia nervosa ( 23568457)
Protein-Protein Interactions		30 interactors: ACTN1 APP CEP350 EDF1 EIF3I FOXO3 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA RARA RXRA RXRB RXRG SIRT1 SRC SS18L1 SUV39H1 SYT1 TMEM161A ZXDC	6 interactors: APTX NR1H3 PLEKHA5 PPARA PPARD PPARG
Entrez ID		10062	9857
HPRD ID		07211	09870
Ensembl ID		ENSG00000025434	ENSG00000135837
Uniprot IDs		B4DXU5 F1D8N1 Q13133	Q5VT06
PDB IDs		1UHL 3IPQ 3IPS 3IPU	2COZ
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Metabolic Process Steroid Hormone Mediated Signaling Pathway Reproductive Structure Development Reproductive System Development Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Developmental Process Involved In Reproduction Organ Development Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Cyclic Compound Retinoic Acid Receptor Signaling Pathway Reproductive Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Negative Regulation Of Cholesterol Storage Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Negative Regulation Of Lipid Storage Hormone-mediated Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Storage Fatty Acid Transport Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Multicellular Organismal Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Lipid Transport Negative Regulation Of Sequestering Of Triglyceride Regulation Of Circadian Rhythm Cellular Response To Lipid Negative Regulation Of Inflammatory Response Response To Steroid Hormone Monocarboxylic Acid Transport Positive Regulation Of Fatty Acid Oxidation Cellular Response To Hormone Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Vitamin A Regulation Of Fatty Acid Oxidation Response To Lipid Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Regulation Of Inflammatory Response Regulation Of Collagen Metabolic Process Response To Hormone Regulation Of Cholesterol Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Lipid Metabolic Process Cellular Lipid Metabolic Process Lipid Transport Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Response To Cytokine Stimulus Fatty Acid Metabolic Process
Tagcloud ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Intersection) ?