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NR1H3 and TMEM161A
Number of citations of the paper that reports this interaction (PubMedID
15604093
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
NR1H3
TMEM161A
Description
nuclear receptor subfamily 1 group H member 3
transmembrane protein 161A
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Membrane
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Cholesterol Binding
Chromatin DNA Binding
Sterol Response Element Binding
Sequence-specific DNA Binding
Metal Ion Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Lipid Metabolic Process
Hormone-mediated Signaling Pathway
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Negative Regulation Of Cholesterol Storage
Cell Differentiation
Intracellular Receptor Signaling Pathway
Negative Regulation Of Lipid Transport
Positive Regulation Of Cholesterol Transport
Response To Progesterone
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Phosphatidylcholine Acyl-chain Remodeling
Cholesterol Homeostasis
Regulation Of Circadian Rhythm
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Macrophage Activation
Apoptotic Cell Clearance
Positive Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Lipid Biosynthetic Process
Negative Regulation Of Pinocytosis
Negative Regulation Of Inflammatory Response
Lipid Homeostasis
Sterol Homeostasis
Negative Regulation Of Type II Interferon-mediated Signaling Pathway
Triglyceride Homeostasis
Cellular Response To Lipopolysaccharide
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Secretion Of Lysosomal Enzymes
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Response To Retinoic Acid
Cellular Response To Oxidative Stress
Cellular Response To UV
Positive Regulation Of DNA Repair
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
PPARA activates gene expression
VLDLR internalisation and degradation
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs
TO-901317
N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diacerein
Rhein
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood glucose levels (
31928498
)
Creatinine levels (
29403010
)
Feeling miserable (
29500382
)
Glycated hemoglobin levels (
34059833
)
HDL cholesterol (
20686565
19060910
)
Hypertension (
31879980
)
Intraocular pressure (
29785010
)
Lymphocyte percentage of white cells (
27863252
)
Metabolic syndrome (
22399527
)
Monocyte percentage of white cells (
27863252
)
Mood instability (
31168069
)
Neurociticism (
29500382
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Triglyceride levels (
32154731
)
Triglycerides (
30275531
)
Interacting Genes
35 interacting genes:
ACTN1
APP
BAG3
CEP350
EDF1
FOXO3
GPANK1
ING3
KAT2B
KDM1A
LZTR1
MDFI
MSTO1
NCOA1
NCOA3
NCOA6
NCOR1
NR0B2
NR3C1
NRIP1
PPARA
PPARD
PPARG
PSMC5
RARA
RXRA
RXRB
RXRG
SIRT1
SS18L1
SUV39H1
SYT1
TMEM161A
UBE2I
ZXDC
12 interacting genes:
AGTR1
CCR2
CHRM5
F2RL1
GNRHR
GPR35
GPR37
NR1H2
NR1H3
OXTR
PTGER4
SLC22A2
Entrez ID
10062
54929
HPRD ID
07211
07905
Ensembl ID
ENSG00000025434
ENSG00000064545
Uniprot IDs
B4DXU5
B5MBY7
F1D8N1
Q13133
K7EPA3
Q9NX61
PDB IDs
1UHL
3IPQ
3IPS
3IPU
5AVI
5AVL
5HJS
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nuclear Receptor-mediated Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Nuclear Receptor Activity
Hormone-mediated Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of MiRNA Transcription
Positive Regulation Of Biosynthetic Process
Chromatin
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Transcription Coactivator Activity
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of MiRNA Metabolic Process
Negative Regulation Of MiRNA Transcription
Intracellular Receptor Signaling Pathway
Negative Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Rhythmic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Nuclear Retinoid X Receptor Binding
Nucleoplasm
RNA Polymerase II Transcription Regulator Complex
Regulation Of Macromolecule Biosynthetic Process
Nuclear Receptor Binding
Retinoic Acid-responsive Element Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Nuclear Steroid Receptor Activity
Regulation Of Programmed Cell Death
Peroxisome Proliferator Activated Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
Regulation Of Lipid Metabolic Process
Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Biosynthetic Process
G Protein-coupled Receptor Activity
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Biological Quality
Regulation Of Body Fluid Levels
Regulation Of Macrophage Derived Foam Cell Differentiation
Regulation Of Cold-induced Thermogenesis
Regulation Of Systemic Arterial Blood Pressure
Negative Regulation Of Pinocytosis
Signal Transduction
Regulation Of Inflammatory Response
Negative Regulation Of Transport
Negative Regulation Of Type II Interferon-mediated Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Defense Response
Negative Regulation Of Cholesterol Storage
Vascular Process In Circulatory System
Regulation Of System Process
Regulation Of Secretion By Cell
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Immune System Process
Negative Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Triglyceride Biosynthetic Process
Regulation Of Type II Interferon-mediated Signaling Pathway
Regulation Of Response To Type II Interferon
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Response To Cytokine Stimulus
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Phosphatidylcholine Acyl-chain Remodeling
Regulation Of Secretion
Circulatory System Process
Regulation Of Lipid Metabolic Process
Regulation Of Triglyceride Biosynthetic Process
Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Dopamine Transport
Negative Regulation Of Lipid Storage
Positive Regulation Of Triglyceride Metabolic Process
Chemokine Receptor Activity
Positive Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Lipid Transport
Positive Regulation Of Lipid Metabolic Process
Apoptotic Cell Clearance
Positive Regulation Of Metabolic Process
Negative Regulation Of Secretion By Cell
Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
Blood Vessel Diameter Maintenance
Regulation Of Tube Size
Plasma Membrane
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Small Molecule Metabolic Process
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