NR1H3 and MSTO1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NR1H3	MSTO1
Gene Name		nuclear receptor subfamily 1, group H, member 3	misato 1, mitochondrial distribution and morphology regulator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex	Cytoplasm Mitochondrial Outer Membrane
	Molecular Function	DNA Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Sterol Response Element Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Molecular_function
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Homeostasis	Mitochondrion Organization Mitochondrion Distribution
Pathways
Drugs
Diseases
GWAS		HDL cholesterol ( 19060910 20686565) Metabolic syndrome ( 22399527)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		30 interactors: ACTN1 APP CEP350 EDF1 EIF3I FOXO3 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA RARA RXRA RXRB RXRG SIRT1 SRC SS18L1 SUV39H1 SYT1 TMEM161A ZXDC	3 interactors: CASP9 EP300 NR1H3
Entrez ID		10062	55154
HPRD ID		07211	16904
Ensembl ID		ENSG00000025434	ENSG00000125459
Uniprot IDs		B4DXU5 F1D8N1 Q13133	Q9BUK6
PDB IDs		1UHL 3IPQ 3IPS 3IPU
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Metabolic Process Steroid Hormone Mediated Signaling Pathway Reproductive Structure Development Reproductive System Development Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Developmental Process Involved In Reproduction Organ Development Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Cyclic Compound Retinoic Acid Receptor Signaling Pathway Reproductive Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Response To Steroid Hormone Response To Lipid Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Organic Cyclic Compound Response To Hormone Histone H2B Acetylation Negative Regulation Of Secretion Of Lysosomal Enzymes Cellular Response To Steroid Hormone Stimulus Intrinsic Apoptotic Signaling Pathway Response To Estrogen Negative Regulation Of Pancreatic Juice Secretion N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Cholesterol Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Negative Regulation Of Pinocytosis Cellular Response To Organic Substance Response To Lipopolysaccharide Regulation Of Tubulin Deacetylation Response To Molecule Of Bacterial Origin Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Cholesterol Storage Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Macrophage Activation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Glial Cell Apoptotic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Cellular Response To Lipid Positive Regulation By Host Of Viral Transcription Positive Regulation Of Receptor Biosynthetic Process Response To Bacterium Response To Organic Substance Positive Regulation Of Cellular Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Toll-like Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Hormone Stimulus Positive Regulation Of Fatty Acid Biosynthetic Process Response To Cobalt Ion Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Homeostasis Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Regulation Of Proteolysis Regulation Of Triglyceride Biosynthetic Process
Tagcloud ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Intersection) ?