NR1H3 and ING3

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NR1H3	ING3
Gene Name		nuclear receptor subfamily 1, group H, member 3	inhibitor of growth family, member 3
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex	Swr1 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	DNA Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Sterol Response Element Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Histone Acetyltransferase Activity Zinc Ion Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Homeostasis	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Histone H2A Acetylation
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		HDL cholesterol ( 19060910 20686565) Metabolic syndrome ( 22399527)
Protein-Protein Interactions		30 interactors: ACTN1 APP CEP350 EDF1 EIF3I FOXO3 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA RARA RXRA RXRB RXRG SIRT1 SRC SS18L1 SUV39H1 SYT1 TMEM161A ZXDC	7 interactors: APP FBXO25 NR1H2 NR1H3 TEX11 TRIM54 USHBP1
Entrez ID		10062	54556
HPRD ID		07211	06321
Ensembl ID		ENSG00000025434	ENSG00000071243
Uniprot IDs		B4DXU5 F1D8N1 Q13133	Q9NXR8
PDB IDs		1UHL 3IPQ 3IPS 3IPU	1X4I
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Metabolic Process Steroid Hormone Mediated Signaling Pathway Reproductive Structure Development Reproductive System Development Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Developmental Process Involved In Reproduction Organ Development Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Cyclic Compound Retinoic Acid Receptor Signaling Pathway Reproductive Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Negative Regulation Of Pinocytosis Negative Regulation Of Cholesterol Storage Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Efflux Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Cholesterol Efflux Regulation Of Triglyceride Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Transport Regulation Of Triglyceride Metabolic Process Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Endocytosis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Lipid Storage Positive Regulation Of Lipid Transport Regulation Of Protein Processing Positive Regulation Of Lipid Biosynthetic Process Cholesterol Homeostasis Sterol Homeostasis Regulation Of Cellular Ketone Metabolic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipase Activity Regulation Of Lipid Transport Steroid Hormone Mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Lipid Homeostasis Regulation Of Proteolysis Negative Regulation Of Immune Response Hormone-mediated Signaling Pathway Regulation Of Lipid Biosynthetic Process Synaptic Growth At Neuromuscular Junction
Tagcloud ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	adenocarcinoma adenoma carcinogenesis clinicopathological colo201 colo205 colorectal depth dld downregulated forming hct ht immunohistochemically interpretation invasion kaplan km lymphatic meier mucosa neoplastic nnm node staging sw480 sw620 venous widr
Tagcloud (Difference) ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	adenocarcinoma adenoma carcinogenesis clinicopathological colo201 colo205 colorectal depth dld downregulated forming hct ht immunohistochemically interpretation invasion kaplan km lymphatic meier mucosa neoplastic nnm node staging sw480 sw620 venous widr
Tagcloud (Intersection) ?