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BRCC3 and UIMC1
Number of citations of the paper that reports this interaction (PMID
19202061
)
54
Data Source:
BioGRID
(pull down, affinity chromatography technology)
BRCC3
UIMC1
Gene Name
BRCA1/BRCA2-containing complex, subunit 3
ubiquitin interaction motif containing 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
BRCA1-A Complex
BRISC Complex
Nucleus
BRCA1-A Complex
Molecular Function
Ubiquitin-specific Protease Activity
Protein Binding
Metallopeptidase Activity
Enzyme Regulator Activity
Polyubiquitin Binding
Metal Ion Binding
Protein Binding
Histone Binding
Retinoid X Receptor Binding
K63-linked Polyubiquitin Binding
Biological Process
Double-strand Break Repair
Proteolysis
Response To X-ray
Response To Ionizing Radiation
G2 DNA Damage Checkpoint
Positive Regulation Of DNA Repair
Regulation Of Catalytic Activity
Protein K63-linked Deubiquitination
Histone H2A K63-linked Deubiquitination
Double-strand Break Repair
Transcription, DNA-templated
Response To Ionizing Radiation
G2 DNA Damage Checkpoint
Positive Regulation Of DNA Repair
Negative Regulation Of Transcription, DNA-templated
Histone H2A K63-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS
Activated partial thromboplastin time (
22703881
)
Menarche and menopause (age at onset) (
19448621
)
Menopause (age at onset) (
22267201
)
Protein-Protein Interactions
7 interactors:
BRCA1
FANCG
SNAPC5
SUMO2
UBC
UBE2D1
UIMC1
14 interactors:
ATP8A2
BABAM1
BRCC3
CEP57
ESR1
FAM175A
FANCG
HIST2H2AC
INO80B
KIAA0368
MDC1
NR6A1
SKIL
TP53
Entrez ID
79184
51720
HPRD ID
06465
11482
Ensembl ID
ENSG00000185515
ENSG00000087206
Uniprot IDs
P46736
Q96RL1
PDB IDs
2RR9
Enriched GO Terms of Interacting Partners
?
Cell Cycle Checkpoint
Cell Cycle Process
Response To Abiotic Stimulus
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
DNA Damage Checkpoint
Cell Cycle
DNA Repair
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Cellular Response To Stress
Regulation Of Protein Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Protein Catabolic Process
DNA-templated Transcription, Initiation
G2 DNA Damage Checkpoint
Positive Regulation Of DNA Repair
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Proteolysis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of DNA-templated Transcription In Response To Stress
DNA Metabolic Process
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Negative Regulation Of Transcription, DNA-templated
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of DNA Repair
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Response To DNA Damage Stimulus
MyD88-independent Toll-like Receptor Signaling Pathway
Negative Regulation Of RNA Biosynthetic Process
Toll-like Receptor 3 Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Metabolic Process
Response To Radiation
Negative Regulation Of Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Chromosome Organization
Regulation Of Cell Cycle Process
Cell Cycle Checkpoint
Double-strand Break Repair
DNA Repair
DNA Damage Checkpoint
Cell Cycle Process
Positive Regulation Of Response To DNA Damage Stimulus
Response To Radiation
Cellular Response To DNA Damage Stimulus
Cell Cycle
Positive Regulation Of DNA Repair
Regulation Of Response To DNA Damage Stimulus
DNA Metabolic Process
G2 DNA Damage Checkpoint
Response To Ionizing Radiation
Chromatin Organization
Regulation Of DNA Repair
Cellular Response To Stress
Organelle Organization
Chromosome Organization
Chromatin Modification
Response To Abiotic Stimulus
Nucleobase-containing Compound Metabolic Process
Protein K63-linked Deubiquitination
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Multicellular Organismal Reproductive Process
Positive Regulation Of DNA Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Multicellular Organism Reproduction
Protein Import Into Nucleus, Translocation
Cellular Response To Stimulus
Response To Stimulus
Transcription Initiation From RNA Polymerase II Promoter
Response To X-ray
Spermatogenesis
Male Gamete Generation
Nitrogen Compound Metabolic Process
Reproduction
DNA-templated Transcription, Initiation
Single Organism Reproductive Process
Gamete Generation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Response To Antibiotic
Reproductive Process
Rhythmic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ovarian Follicle Development
Sexual Reproduction
Negative Regulation Of Macromitophagy
Oligodendrocyte Apoptotic Process
Tagcloud
?
break
brip1
carcinogen
carcinogenic
ccna2
ccnb1
ccng1
chek1
cor
cyce1
deregulated
dsb
genotoxicity
gpt
kidneys
medulla
ochratoxin
om
ota
outer
phlda3
possessed
rad18
rodents
s3
segment
tubules
tumorigenicity
wee1
Tagcloud (Difference)
?
break
brip1
carcinogen
carcinogenic
ccna2
ccnb1
ccng1
chek1
cor
cyce1
deregulated
dsb
genotoxicity
gpt
kidneys
medulla
ochratoxin
om
ota
outer
phlda3
possessed
rad18
rodents
s3
segment
tubules
tumorigenicity
wee1
Tagcloud (Intersection)
?