UIMC1 and BABAM1

Number of citations of the paper that reports this interaction (PMID 19261748)
44

Data Source:
BioGRID (pull down)

		UIMC1	BABAM1
Gene Name		ubiquitin interaction motif containing 1	BRISC and BRCA1 A complex member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus BRCA1-A Complex	Nucleus Nucleoplasm Cytoplasm BRCA1-A Complex BRISC Complex
	Molecular Function	Protein Binding Histone Binding Retinoid X Receptor Binding K63-linked Polyubiquitin Binding	Protein Binding
	Biological Process	Double-strand Break Repair Transcription, DNA-templated Response To Ionizing Radiation G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination	Double-strand Break Repair Response To Ionizing Radiation Chromatin Modification G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Protein K63-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		14 interactors: ATP8A2 BABAM1 BRCC3 CEP57 ESR1 FAM175A FANCG HIST2H2AC INO80B KIAA0368 MDC1 NR6A1 SKIL TP53	5 interactors: BRCA1 BRE TERF2IP TRIM27 UIMC1
Entrez ID		51720	29086
HPRD ID		11482	13702
Ensembl ID		ENSG00000087206	ENSG00000105393
Uniprot IDs		Q96RL1	M0QX07 Q9NWV8
PDB IDs		2RR9
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Double-strand Break Repair DNA Repair DNA Damage Checkpoint Cell Cycle Process Positive Regulation Of Response To DNA Damage Stimulus Response To Radiation Cellular Response To DNA Damage Stimulus Cell Cycle Positive Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus DNA Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Chromatin Organization Regulation Of DNA Repair Cellular Response To Stress Organelle Organization Chromosome Organization Chromatin Modification Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Protein K63-linked Deubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Multicellular Organismal Reproductive Process Positive Regulation Of DNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organism Reproduction Protein Import Into Nucleus, Translocation Cellular Response To Stimulus Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Response To X-ray Spermatogenesis Male Gamete Generation Nitrogen Compound Metabolic Process Reproduction DNA-templated Transcription, Initiation Single Organism Reproductive Process Gamete Generation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Antibiotic Reproductive Process Rhythmic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ovarian Follicle Development Sexual Reproduction Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process	Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Metabolic Process Organelle Organization Response To Radiation Response To Stress Cellular Response To Stress Negative Regulation Of Chromosome Organization DNA Repair Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of DNA Recombination At Telomere Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Organelle Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Histone H2A K63-linked Deubiquitination Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Gene Expression, Epigenetic Chromosome Organization Cell Cycle Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Protection From Non-homologous End Joining At Telomere Cellular Response To Indole-3-methanol Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Centriole Replication Negative Regulation Of Calcium Ion Import Telomere Capping Protein Localization To Chromosome, Telomeric Region
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