BRCC3

Description		BRCA1/BRCA2-containing complex subunit 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton BRCA1-A Complex BRISC Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization Proteolysis DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Response To Ionizing Radiation Protein Deubiquitination NLRP3 Inflammasome Complex Assembly Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Cellular Response To Ionizing Radiation DNA Repair-dependent Chromatin Remodeling Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of DNA Damage Checkpoint
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Venous thromboembolism ( 31676865)
Novel Interacting Genes		1 novel interacting genes: ICOS
Interacting Genes		13 interacting genes: ANKRD11 BACH1 BRCA1 CD82 FANCG IFNAR1 ITSN1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1
Entrez ID		79184
HPRD ID		06465
Ensembl ID		ENSG00000185515
Uniprot IDs		P46736
PDB IDs		6H3C 6R8F 8PVY 8PY2
Enriched GO Terms of Interacting Partners?		Nucleoplasm Post-translational Protein Modification Histone H2AK127 Ubiquitin Ligase Activity Damaged DNA Binding Tubulin Binding Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Type I Interferon Receptor Activity Type I Interferon Binding Regulation Of Cellular Respiration Interferon Receptor Activity Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Lateral Cell Cortex Positive Regulation Of Mitotic Spindle Elongation Clathrin-dependent Synaptic Vesicle Endocytosis L-allo-threonine Aldolase Activity Glycine Hydroxymethyltransferase Activity Glycine Biosynthetic Process From Serine Protein Tag Activity Ubiquitin Protein Ligase Binding
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