BRCC3

Gene Name		BRCA1/BRCA2-containing complex, subunit 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm BRCA1-A Complex BRISC Complex
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Proteolysis Response To X-ray Response To Ionizing Radiation G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: BRCA1 FANCG SNAPC5 SUMO2 UBC UBE2D1 UIMC1
Entrez ID		79184
HPRD ID		06465
Ensembl ID		ENSG00000185515
Uniprot IDs		P46736
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Cell Cycle Process Response To Abiotic Stimulus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Cell Cycle DNA Repair Protein Polyubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Stress Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Catabolic Process DNA-templated Transcription, Initiation G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Transcription, DNA-templated TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of DNA Repair Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Response To DNA Damage Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Toll-like Receptor 3 Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Positive Regulation Of Protein Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Process
Tagcloud ?		break brip1 carcinogen carcinogenic ccna2 ccnb1 ccng1 chek1 cor cyce1 deregulated dsb genotoxicity gpt kidneys medulla ochratoxin om ota outer phlda3 possessed rad18 rodents s3 segment tubules tumorigenicity wee1