UIMC1 and BRCC3

Number of citations of the paper that reports this interaction (PMID 19202061)
54

Data Source:
BioGRID (pull down, affinity chromatography technology)

		UIMC1	BRCC3
Gene Name		ubiquitin interaction motif containing 1	BRCA1/BRCA2-containing complex, subunit 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus BRCA1-A Complex	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm BRCA1-A Complex BRISC Complex
	Molecular Function	Protein Binding Histone Binding Retinoid X Receptor Binding K63-linked Polyubiquitin Binding	Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Transcription, DNA-templated Response To Ionizing Radiation G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination	Double-strand Break Repair Proteolysis Response To X-ray Response To Ionizing Radiation G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		14 interactors: ATP8A2 BABAM1 BRCC3 CEP57 ESR1 FAM175A FANCG HIST2H2AC INO80B KIAA0368 MDC1 NR6A1 SKIL TP53	7 interactors: BRCA1 FANCG SNAPC5 SUMO2 UBC UBE2D1 UIMC1
Entrez ID		51720	79184
HPRD ID		11482	06465
Ensembl ID		ENSG00000087206	ENSG00000185515
Uniprot IDs		Q96RL1	P46736
PDB IDs		2RR9
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Double-strand Break Repair DNA Repair DNA Damage Checkpoint Cell Cycle Process Positive Regulation Of Response To DNA Damage Stimulus Response To Radiation Cellular Response To DNA Damage Stimulus Cell Cycle Positive Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus DNA Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Chromatin Organization Regulation Of DNA Repair Cellular Response To Stress Organelle Organization Chromosome Organization Chromatin Modification Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Protein K63-linked Deubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Multicellular Organismal Reproductive Process Positive Regulation Of DNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organism Reproduction Protein Import Into Nucleus, Translocation Cellular Response To Stimulus Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Response To X-ray Spermatogenesis Male Gamete Generation Nitrogen Compound Metabolic Process Reproduction DNA-templated Transcription, Initiation Single Organism Reproductive Process Gamete Generation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Antibiotic Reproductive Process Rhythmic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ovarian Follicle Development Sexual Reproduction Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process	Cell Cycle Checkpoint Cell Cycle Process Response To Abiotic Stimulus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Cell Cycle DNA Repair Protein Polyubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Stress Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Catabolic Process DNA-templated Transcription, Initiation G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Transcription, DNA-templated TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of DNA Repair Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Response To DNA Damage Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Toll-like Receptor 3 Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Positive Regulation Of Protein Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Process
Tagcloud ?			break brip1 carcinogen carcinogenic ccna2 ccnb1 ccng1 chek1 cor cyce1 deregulated dsb genotoxicity gpt kidneys medulla ochratoxin om ota outer phlda3 possessed rad18 rodents s3 segment tubules tumorigenicity wee1
Tagcloud (Difference) ?			break brip1 carcinogen carcinogenic ccna2 ccnb1 ccng1 chek1 cor cyce1 deregulated dsb genotoxicity gpt kidneys medulla ochratoxin om ota outer phlda3 possessed rad18 rodents s3 segment tubules tumorigenicity wee1
Tagcloud (Intersection) ?