FGA and SERPINA5

Number of citations of the paper that reports this interaction (PubMedID 8589203)
0

Data Source:
HPRD (in vitro)

		FGA	SERPINA5
Description		fibrinogen alpha chain	serpin family A member 5
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle Extracellular Vesicle	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Extracellular Matrix Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Cell Adhesion Molecule Binding	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity Phosphatidylcholine Binding Acrosin Binding
	Biological Process	Adaptive Immune Response Immune System Process Cell-matrix Adhesion Blood Coagulation Hemostasis Platelet Activation Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Fibrinolysis Induction Of Bacterial Agglutination Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation, Common Pathway Negative Regulation Of Endothelial Cell Apoptotic Process	Lipid Transport Spermatogenesis Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Seminal Clot Liquefaction
Pathways		Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants Amyloid fiber formation	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation
Drugs		Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Zinc Alfimeprase Ancrod EP-2104R Lanoteplase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Urokinase Drotrecogin alfa Tifuvirtide PPL-100
Diseases		Familial amyloidosis Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia
GWAS		D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494 30659681 33592630)	Blood protein levels ( 30072576) Serum albumin levels ( 29403010) Serum total protein levels ( 29403010)
Interacting Genes		30 interacting genes: AGTRAP APP CDH5 EXOC5 F13A1 F2 FGB FGG HRG HSP90AA1 ITGA2B ITGB3 LRP1B MEOX2 NID1 PLAT PRRC2A SERPINA5 SERPINF2 SH3BP1 STX1B STX2 SYCE1L TFIP11 THBS1 TMEM43 TPM1 TPM3 UBC VWF	22 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD
Entrez ID		2243	5104
HPRD ID		00619	03503
Ensembl ID		ENSG00000171560	ENSG00000188488
Uniprot IDs		P02671	B4DDH1 P05154
PDB IDs		1BBR 1DM4 1FPH 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27 5CFA	1LQ8 2HI9 2OL2 3DY0
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Lumen Platelet Alpha Granule Fibrinolysis Blood Coagulation, Fibrin Clot Formation Extracellular Matrix Negative Regulation Of Fibrinolysis Coagulation Blood Coagulation Hemostasis Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Regulation Of Hemostasis Regulation Of Fibrinolysis Protein Activation Cascade Negative Regulation Of Blood Coagulation Fibrinogen Binding Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinogen Complex Positive Regulation Of Blood Coagulation Extracellular Exosome Blood Microparticle Positive Regulation Of Coagulation Platelet Activation Negative Regulation Of Wound Healing Regulation Of Wound Healing External Side Of Plasma Membrane Cell Surface Regulation Of Response To Wounding Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Wound Healing Negative Regulation Of Plasminogen Activation Extracellular Matrix Binding Cell-substrate Adhesion Regulation Of Biological Quality Signaling Receptor Binding Negative Regulation Of Endothelial Cell Apoptotic Process Plasminogen Activation Cell-matrix Adhesion Protease Binding Extracellular Matrix Structural Constituent Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Plasminogen Activation Extracellular Space Negative Regulation Of Protein Processing Heparin Binding Integrin AlphaIIb-beta3 Complex Negative Regulation Of Protein Maturation Membrane Organization	Zymogen Activation Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Blood Coagulation Hemostasis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Plasminogen Activation Regulation Of Hemostasis Serine-type Peptidase Activity Serine-type Endopeptidase Activity Fibrinolysis Protein Processing Regulation Of Wound Healing Proteolysis Regulation Of Response To Wounding Regulation Of Body Fluid Levels Regulation Of Fibrinolysis Protein Maturation Peptidase Activity Extracellular Space Protein Metabolic Process Regulation Of Biological Quality Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Region Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process Protein Activation Cascade Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Hydrolase Activity External Side Of Plasma Membrane Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Protein Maturation Positive Regulation Of Wound Healing Blood Coagulation, Common Pathway Platelet Activation Platelet Alpha Granule Negative Regulation Of Protein Maturation Positive Regulation Of Vasoconstriction Regulation Of Proteolysis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Secretory Granule Positive Regulation Of Fibrinolysis Regulation Of Protein Metabolic Process
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