FGA and FGG

Number of citations of the paper that reports this interaction (PubMedID 12356313)
0

Data Source:
HPRD (in vitro)

		FGA	FGG
Description		fibrinogen alpha chain	fibrinogen gamma chain
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle Extracellular Vesicle	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Cell Adhesion Molecule Binding	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Adaptive Immune Response Immune System Process Cell-matrix Adhesion Blood Coagulation Hemostasis Platelet Activation Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Fibrinolysis Induction Of Bacterial Agglutination Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation, Common Pathway Negative Regulation Of Endothelial Cell Apoptotic Process	Cell-matrix Adhesion Blood Coagulation Hemostasis Protein Secretion Platelet Activation Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Fibrinolysis Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants Amyloid fiber formation	Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Zinc Alfimeprase Ancrod EP-2104R Lanoteplase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Alteplase Sucralfate Thrombin Human thrombin Thrombin alfa
Diseases		Familial amyloidosis Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia	Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia
GWAS		D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494 30659681 33592630)	Activated partial thromboplastin time ( 29403010) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Fibrinogen levels ( 26561523) Glycine levels ( 30837465) Prothrombin time ( 29403010) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 30659681 31420334 31676865)
Interacting Genes		30 interacting genes: AGTRAP APP CDH5 EXOC5 F13A1 F2 FGB FGG HRG HSP90AA1 ITGA2B ITGB3 LRP1B MEOX2 NID1 PLAT PRRC2A SERPINA5 SERPINF2 SH3BP1 STX1B STX2 SYCE1L TFIP11 THBS1 TMEM43 TPM1 TPM3 UBC VWF	13 interacting genes: APP F13A1 F13B FGA FGB ICAM1 ITGA2B ITGAM ITGB3 SERPINA5 VKORC1 VTN VWF
Entrez ID		2243	2266
HPRD ID		00619	00621
Ensembl ID		ENSG00000171560	ENSG00000171557
Uniprot IDs		P02671	A0A140VJJ6 P02679
PDB IDs		1BBR 1DM4 1FPH 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27 5CFA	1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS 4B60
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Lumen Platelet Alpha Granule Fibrinolysis Blood Coagulation, Fibrin Clot Formation Extracellular Matrix Negative Regulation Of Fibrinolysis Coagulation Blood Coagulation Hemostasis Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Regulation Of Hemostasis Regulation Of Fibrinolysis Protein Activation Cascade Negative Regulation Of Blood Coagulation Fibrinogen Binding Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinogen Complex Positive Regulation Of Blood Coagulation Extracellular Exosome Blood Microparticle Positive Regulation Of Coagulation Platelet Activation Negative Regulation Of Wound Healing Regulation Of Wound Healing External Side Of Plasma Membrane Cell Surface Regulation Of Response To Wounding Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Wound Healing Negative Regulation Of Plasminogen Activation Extracellular Matrix Binding Cell-substrate Adhesion Regulation Of Biological Quality Signaling Receptor Binding Negative Regulation Of Endothelial Cell Apoptotic Process Plasminogen Activation Cell-matrix Adhesion Protease Binding Extracellular Matrix Structural Constituent Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Plasminogen Activation Extracellular Space Negative Regulation Of Protein Processing Heparin Binding Integrin AlphaIIb-beta3 Complex Negative Regulation Of Protein Maturation Membrane Organization	Blood Coagulation, Fibrin Clot Formation Coagulation Blood Coagulation Hemostasis Platelet Alpha Granule Protein Activation Cascade Regulation Of Body Fluid Levels Cell-substrate Adhesion External Side Of Plasma Membrane Cell-matrix Adhesion Integrin Binding Platelet Alpha Granule Lumen Cell Adhesion Extracellular Space Extracellular Matrix Negative Regulation Of Endothelial Cell Apoptotic Process Blood Microparticle Regulation Of Endothelial Cell Apoptotic Process Extracellular Exosome Cell Surface Platelet Activation Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Integrin-mediated Signaling Pathway Cell-cell Adhesion Integrin Complex Cell Adhesion Mediated By Integrin Regulation Of ERK1 And ERK2 Cascade Regulation Of Vesicle-mediated Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extracellular Matrix Structural Constituent Extracellular Matrix Binding Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Positive Regulation Of Cell-substrate Adhesion Protein Maturation Positive Regulation Of Leukocyte Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Extrinsic Apoptotic Signaling Pathway Induction Of Bacterial Agglutination Negative Regulation Of Blood Coagulation Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinogen Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Antibacterial Humoral Response Homotypic Cell-cell Adhesion Positive Regulation Of MAPK Cascade
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