FGA and PLAT

Number of citations of the paper that reports this interaction (PMID 11170397)
13

Data Source:
HPRD (in vitro, in vivo)

		FGA	PLAT
Gene Name		fibrinogen alpha chain	plasminogen activator, tissue
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Vesicle Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Synapse Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Structural Molecule Activity Protein Binding Protein Binding, Bridging Cell Adhesion Molecule Binding	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation, Common Pathway Negative Regulation Of Endothelial Cell Apoptotic Process	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Synaptic Transmission, Glutamatergic Fibrinolysis Response To Peptide Hormone Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Response To CAMP Transmembrane Transport Positive Regulation Of Ovulation Cellular Response To Dexamethasone Stimulus
Pathways		p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Amyloids Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Signaling by PDGF Dissolution of Fibrin Clot Orphan transporters
Drugs		Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Alpha-D-Mannose	Urokinase Aminocaproic Acid Ibuprofen Iloprost 6-Amino Hexanoic Acid 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Diseases
GWAS		D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494)
Protein-Protein Interactions		15 interactors: CDH5 F13A1 F2 FGB FGG HRG ITGA2B ITGB3 NID1 PLAT PRRC2A SERPINA5 SERPINF2 THBS1 UBC	25 interactors: ANXA2 CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LAMA5 LRP1 LRP1B MAPK1 MAPK3 PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SPARC
Entrez ID		2243	5327
HPRD ID		00619	01419
Ensembl ID		ENSG00000171560	ENSG00000104368
Uniprot IDs		P02671	B4DN26 B4DNJ1 P00750
PDB IDs		1BBR 1DM4 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27	1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Exocytosis Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Fibrinolysis Secretion By Cell Extracellular Matrix Organization Extracellular Structure Organization Secretion Fibrinolysis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell-substrate Adhesion Platelet Aggregation Response To Stress Positive Regulation Of Coagulation Regulation Of Wound Healing Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cell-matrix Adhesion Negative Regulation Of Coagulation Regulation Of Proteolysis Positive Regulation Of Cell Adhesion Negative Regulation Of Wound Healing Regulation Of Protein Processing Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Establishment Of Localization In Cell Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cell Adhesion Regulation Of Endothelial Cell Apoptotic Process Cellular Localization Negative Regulation Of Endothelial Cell Chemotaxis Cell Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Fibrinolysis Wound Healing Negative Regulation Of Coagulation Platelet Activation Negative Regulation Of Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Cell Migration Regulation Of Blood Coagulation Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Wound Healing Vesicle-mediated Transport Cardiovascular System Development Regulation Of Cell Adhesion Multicellular Organismal Development Developmental Process Cell Activation System Development Anatomical Structure Development Blood Vessel Development Regulation Of Protein Metabolic Process Vasculature Development Regulation Of Vesicle-mediated Transport Regulation Of Catalytic Activity Response To Stress Exocytosis Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cellular Protein Metabolic Process Receptor-mediated Endocytosis Response To Stimulus Regulation Of Cell-substrate Adhesion Locomotion Secretion Regulation Of Peptidase Activity Extracellular Matrix Disassembly Blood Vessel Morphogenesis Regulation Of Smooth Muscle Cell-matrix Adhesion Response To External Stimulus Regulation Of Golgi Inheritance Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component
Tagcloud ?		antipsychotic antipsychotics app began caution combinations commonly concurrent contrasts dementia exploring hazardous hospitalized hypnotics monotherapy odds polypharmacy prescribed prescribing quetiapine risperidone schizophrenia sedatives sga taiwan tolerability trends warning warranted	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Difference) ?		antipsychotic antipsychotics app began caution combinations commonly concurrent contrasts dementia exploring hazardous hospitalized hypnotics monotherapy odds polypharmacy prescribed prescribing quetiapine risperidone schizophrenia sedatives sga taiwan tolerability trends warning warranted	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Intersection) ?