CDK19 and SRSF7

Number of citations of the paper that reports this interaction (PubMedID 12501247)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo)

		CDK19	SRSF7
Description		cyclin dependent kinase 19	serine and arginine rich splicing factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm CKM Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Apoptotic Process Regulation Of Cell Cycle Cellular Response To Lipopolysaccharide	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Myeloperoxidase-DNA complexes ( 33717105) Zinc levels ( 26025379)
Interacting Genes		7 interacting genes: BCL6 EIF3F PRMT5 SMARCA4 SRSF7 SUZ12 WDR77	20 interacting genes: CCNL2 CDK19 CDK6 CEBPA CPSF6 DUSP11 FBXO7 LUC7L LUC7L2 NEDD4 NXF1 OGT PCBP2 PRPF38A RNPS1 SDCBP SREK1 SRPK1 SRPK2 UBC
Entrez ID		23097	6432
HPRD ID		07627	08991
Ensembl ID		ENSG00000155111	ENSG00000115875
Uniprot IDs		B4DUB1 F6QTA4 I6W807 Q9BWU1	C9JAB2 Q16629
PDB IDs			2HVZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Developmental Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RSC-type Complex Methylosome Negative Regulation Of Gene Expression Regulation Of RNA Splicing Methyl-CpG Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Transcription Corepressor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle DNA Replication P53 Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Oocyte Axis Specification Chromatin DNA Binding Cysteine-type Deubiquitinase Activity Positive Regulation Of Cell Development Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Plasma Cell Differentiation Peptidyl-arginine N-methylation Regulation Of RNA Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Isotype Switching To IgE Isotypes Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of T Cell Differentiation Chromatin Binding Regulation Of Mitotic Cell Cycle Intronic Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Biosynthetic Process Protein-containing Complex Assembly Cysteine-type Peptidase Activity	Nucleoplasm Nuclear Speck Nucleus RNA Binding MRNA Metabolic Process MRNA Binding MRNA Processing RNA Metabolic Process Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding RNA Splicing Protein-RNA Complex Assembly Regulation Of Cell Cycle U2-type Prespliceosome U1 SnRNP Macromolecule Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Protein Serine Kinase Activity Cyclin D2-CDK6 Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Formation Of Structure Involved In A Symbiotic Process Interleukin-5 Receptor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Exon-exon Junction Complex Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Protein Targeting Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Response To Vitamin B2 C/EBP Complex Protein Localization To Lysosome Protein Modification Process Channel Inhibitor Activity
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