CDK19 and EIF3F

Number of citations of the paper that reports this interaction (PMID 12446680)
21

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CDK19	EIF3F
Gene Name		cyclin-dependent kinase 19	eukaryotic translation initiation factor 3, subunit F
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding	Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Protein Phosphorylation Regulation Of Cell Cycle	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Proteolysis Gene Expression Protein Deubiquitination Cellular Protein Metabolic Process
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS			Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		5 interactors: BCL6 EIF3F SMARCA4 SRSF7 SUZ12	17 interactors: APP ATXN1 CDK11A CDK11B CDK19 DKC1 EEF1A1 EIF3M FBXO32 HAX1 HNRNPK HTR2A MTOR PTN SHBG SMAD9 UBC
Entrez ID		23097	8665
HPRD ID		07627	04887
Ensembl ID		ENSG00000155111	ENSG00000175390
Uniprot IDs		B4DUB1 Q9BWU1	B4DEW9 O00303
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Erythrocyte Differentiation Erythrocyte Homeostasis Negative Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Myeloid Cell Homeostasis Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Negative Regulation Of Cell Growth Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Gene Expression, Epigenetic Negative Regulation Of T-helper 2 Cell Differentiation DNA Methylation On Cytosine Within A CG Sequence Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Homeostasis Of Number Of Cells Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Growth Myeloid Cell Differentiation Definitive Erythrocyte Differentiation Aortic Smooth Muscle Cell Differentiation Nucleocytoplasmic Transport Nuclear Transport RNA Metabolic Process Glial Cell Fate Determination Methylation-dependent Chromatin Silencing Regulation Of Memory T Cell Differentiation Negative Regulation Of Cellular Senescence Negative Regulation Of Biosynthetic Process Type 2 Immune Response Regulation Of Cell Growth Positive Regulation By Host Of Viral Transcription Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Cell Aging DNA Methylation On Cytosine Regulation Of Cell Differentiation Histone Modification Negative Regulation Of Alpha-beta T Cell Differentiation Germinal Center Formation	Positive Regulation Of Cellular Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Learning Or Memory Positive Regulation Of Macromolecule Biosynthetic Process Cognition Positive Regulation Of Gene Expression Response To Abiotic Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Learning Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cell Growth Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Transcription, DNA-templated Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Adult Behavior Regulation Of RNA Biosynthetic Process Single-organism Behavior Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Processing Cellular Response To Growth Factor Stimulus Cell Death Death Regulation Of Protein Phosphorylation Behavior Response To Growth Factor Regulation Of Carbohydrate Utilization Primary Spermatocyte Growth Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Translation Visual Learning Visual Behavior Response To Organic Substance Response To Hypoxia
Tagcloud ?			4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation
Tagcloud (Difference) ?			4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation
Tagcloud (Intersection) ?