PQBP1 and APBB1

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		PQBP1	APBB1
Gene Name		polyglutamine binding protein 1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Nuclear Speck Neuronal Ribonucleoprotein Granule	Nucleus Cytoplasm Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Synapse
	Molecular Function	DNA Binding Transcription Coactivator Activity Ribonucleoprotein Complex Binding	Beta-amyloid Binding Chromatin Binding Protein Binding Transcription Factor Binding Histone Binding Proline-rich Region Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated Neuron Projection Development Regulation Of RNA Splicing Regulation Of Dendrite Morphogenesis	Neuron Migration Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Axon Guidance Visual Learning Extracellular Matrix Organization Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Thymidylate Synthase Biosynthetic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: APBB1 APP AQR ATXN1 C14orf1 CLTB EEF1A1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77	66 interactors: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		10084	322
HPRD ID		02354	04087
Ensembl ID		ENSG00000102103	ENSG00000166313
Uniprot IDs		O60828	O00213
PDB IDs			2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE
Enriched GO Terms of Interacting Partners?		RNA Processing MRNA Processing MRNA Metabolic Process RNA Splicing RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression Visual Learning Visual Behavior Associative Learning Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Response To Light Stimulus Learning Regulation Of Protein Binding Nitrogen Compound Metabolic Process Mitotic Cell Cycle Cell Division Response To Radiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Thymidylate Synthase Biosynthetic Process Respiratory Gaseous Exchange Cell Cycle Regulation Of Neuron Differentiation Regulation Of Binding Learning Or Memory Neurohypophysis Development Synaptic Growth At Neuromuscular Junction Transcription, RNA-templated Cell Cycle Process Negative Regulation Of Neurogenesis Cognition Positive Regulation Of Microtubule Plus-end Binding Collateral Sprouting In Absence Of Injury Golgi Vesicle Fusion To Target Membrane Regulation Of Nitrogen Compound Metabolic Process Mitotic Nuclear Division Response To Abiotic Stimulus Positive Regulation Of Cellular Biosynthetic Process Ribonucleoprotein Complex Biogenesis Mitotic Cell Cycle Process Neuron Differentiation Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Development Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Nucleic Acid-templated Transcription	RNA Processing MRNA Processing MRNA Metabolic Process RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Actin Polymerization Or Depolymerization RNA Biosynthetic Process MRNA 3'-splice Site Recognition Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription, DNA-templated Fc Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Component Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Phagocytosis MRNA 3'-end Processing Cellular Process Regulation Of Metabolic Process Endocytosis Innate Immune Response Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Splicing RNA 3'-end Processing Actin Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Developmental Process Actin Filament-based Process MRNA Stabilization Axon Guidance Positive Regulation Of Actin Nucleation MRNA Polyadenylation
Tagcloud ?		amygdala causative cleaved cognition confirming correspondingly dark declined declines efficiently endogenously exploration kd knock maze object obvious ordinary phenylbutyric polyglutamine possessed prefrontal repetitive rescued retardation suppressing syndromic transgene underlie	a4 additive aging amyloid apba3 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Difference) ?		amygdala causative cleaved cognition confirming correspondingly dark declined declines efficiently endogenously exploration kd knock obvious ordinary phenylbutyric polyglutamine possessed prefrontal repetitive rescued retardation suppressing syndromic transgene underlie	a4 additive aging amyloid apba3 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation mint3 mo muscarinic precursor predisposes secretases signature tauopathy wk
Tagcloud (Intersection) ?		maze object