PQBP1 and CLTB

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PQBP1	CLTB
Description		polyglutamine binding protein 1	clathrin light chain B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Cytoplasmic Stress Granule Microtubule Cytoskeleton Nuclear Body Nuclear Speck Ciliary Basal Body Neuronal Ribonucleoprotein Granule Plasma Membrane Bounded Cell Projection	Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Ciliary Membrane Presynaptic Endocytic Zone Membrane
	Molecular Function	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Ribonucleoprotein Complex Binding	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Regulation Of DNA-templated Transcription MRNA Processing RNA Splicing Neuron Projection Development Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Dendrite Morphogenesis Defense Response To Virus Cellular Response To Exogenous DsRNA	Intracellular Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis
Pathways		mRNA Splicing - Major Pathway	Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		27 interacting genes: APBB1 APP AQR ATXN1 CEBPA CLTB CPSF7 EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RBM22 RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77	11 interacting genes: CALM1 CEBPA CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R HTR4 MYO6 PQBP1 SNCA
Entrez ID		10084	1212
HPRD ID		02354	00352
Ensembl ID		ENSG00000102103	ENSG00000175416
Uniprot IDs		A0A0S2Z4V5 O60828	B4DTF9 P09497
PDB IDs		4BWQ 4BWS 4CDO
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of RNA Splicing	Clathrin Light Chain Binding Endocytosis Clathrin-coated Vesicle Clathrin Coat Assembly Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Import Into Cell Protein Kinase CK2 Complex Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Clathrin-coated Vesicle Membrane Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Clathrin-coated Pit Postsynapse Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Vesicle-mediated Transport Protein-containing Complex Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Catabolic Process Clathrin Adaptor Activity Phospholipid Binding Actin Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Clathrin-coated Endocytic Vesicle PcG Protein Complex Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Receptor-mediated Endocytosis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Cortex Supramolecular Fiber Organization Positive Regulation Of ERBB Signaling Pathway Clathrin Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Actin Filament Binding Regulation Of Cell Cycle Presynaptic Endocytosis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Long-term Synaptic Potentiation Mitochondrion Organization Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Actin Filament Organization Cortical Actin Cytoskeleton Large Intestinal Transit Minus-end Directed Microfilament Motor Activity Response To Desipramine
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