FZD5 and GOPC

Number of citations of the paper that reports this interaction (PMID 11520064)
10

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FZD5	GOPC
Gene Name		frizzled class receptor 5	golgi-associated PDZ and coiled-coil motif containing
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Tight Junction Cell Surface Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Cell Junction Trans-Golgi Network Transport Vesicle Dendrite Protein Complex Postsynaptic Membrane
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity	Small GTPase Regulator Activity Frizzled Binding Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Embryonic Axis Specification Angiogenesis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Tight Junction Assembly	ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Spermatid Nucleus Differentiation Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Regulation Of Catalytic Activity Protein Homooligomerization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Colorectal cancer ( 23266556)
Protein-Protein Interactions		11 interactors: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 UBTD1 WNT5A WNT7A	58 interactors: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CD300C CDC42 CDKN2C CERCAM CFTR CLCN3 CSPG5 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GOLGA3 GRID1 GRID2 HCK IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MUM1 MYLK MYOCD NUP62 PARK7 PID1 RELA RHOQ RNF183 RNF220 RPL13AP17 RTKN SEMA4G SLC25A18 SPATA8 SSNA1 SSTR5 STARD3 STX6 TGFBR2 VIM VTN ZBTB49 ZNF564 ZNF581 ZNF587 ZSCAN1
Entrez ID		7855	57120
HPRD ID		03427	06024
Ensembl ID		ENSG00000163251	ENSG00000047932
Uniprot IDs		Q13467	Q9HD26
PDB IDs			2DC2 2LOB 4E34 4E35
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Embryonic Development Non-canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt Signaling Pathway Cartilage Development Pericardium Morphogenesis Epithelial To Mesenchymal Transition Genitalia Development Negative Regulation Of Signal Transduction Morphogenesis Of An Epithelial Sheet Connective Tissue Development Stem Cell Development Negative Regulation Of Signaling Regulation Of MAPK Cascade Single Organism Reproductive Process Embryonic Digit Morphogenesis Sex Differentiation Regulation Of Phosphorylation Somitogenesis Reproductive Process Developmental Process Involved In Reproduction Stem Cell Differentiation Embryonic Pattern Specification Cell Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Somite Development Primitive Streak Formation Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorus Metabolic Process Palate Development Regulation Of Embryonic Development Axis Specification Segmentation Mesenchymal Cell Development Negative Regulation Of Phosphorylation Convergent Extension Positive Regulation Of Peptidyl-threonine Phosphorylation Uterus Development Mesenchymal Cell Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Dopaminergic Neuron Differentiation Forebrain Development Central Nervous System Development	Cellular Response To Stimulus Cellular Response To Organic Substance Response To External Stimulus Myeloid Leukocyte Differentiation Leukocyte Differentiation Response To Organic Substance Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation Response To Stimulus Cellular Process Cell Communication Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Positive Regulation Of Transport Regulation Of Cellular Process Cell Differentiation Regulation Of Membrane Potential Myeloid Dendritic Cell Differentiation Cellular Response To Hormone Stimulus Signal Transduction Blood Vessel Morphogenesis Myeloid Dendritic Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of DNA Binding Response To Extracellular Stimulus Negative Regulation Of Protein Phosphorylation Cell Death Death Positive Regulation Of Gene Expression T-helper 17 Cell Lineage Commitment Response To Lipid Regulation Of Phosphorylation Cellular Localization Membrane Hyperpolarization Negative Regulation Of Cell Proliferation Defense Response Regulation Of Signaling Response To Drug Positive Regulation Of DNA Binding Blood Vessel Development Response To Mechanical Stimulus Response To Stress Signaling Response To Cytokine T-helper 17 Cell Differentiation Dendritic Cell Differentiation Response To Other Organism
Tagcloud ?		aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring	admissions attained clinicaltrials clinics dbp empowering empowerment equation estimating estimation generalized gov hba1c hong inpatient kong nct01935349 outpatient pep programme registration sbp september service sopc specialist t2dm utilization visits
Tagcloud (Difference) ?		aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring	admissions attained clinicaltrials clinics dbp empowering empowerment equation estimating estimation generalized gov hba1c hong inpatient kong nct01935349 outpatient pep programme registration sbp september service sopc specialist t2dm utilization visits
Tagcloud (Intersection) ?