FZD5 and ABI3BP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FZD5	ABI3BP
Gene Name		frizzled class receptor 5	ABI family, member 3 (NESH) binding protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Tight Junction Cell Surface Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm	Interstitial Matrix Extracellular Space Extracellular Matrix
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity	Collagen Binding Heparin Binding
	Biological Process	Embryonic Axis Specification Angiogenesis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Tight Junction Assembly	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 UBTD1 WNT5A WNT7A	6 interactors: ABI3 CBX1 FZD5 GOT1 GRB2 MBNL1
Entrez ID		7855	25890
HPRD ID		03427	09380
Ensembl ID		ENSG00000163251	ENSG00000154175
Uniprot IDs		Q13467	D3YTG3 Q7Z7G0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Embryonic Development Non-canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt Signaling Pathway Cartilage Development Pericardium Morphogenesis Epithelial To Mesenchymal Transition Genitalia Development Negative Regulation Of Signal Transduction Morphogenesis Of An Epithelial Sheet Connective Tissue Development Stem Cell Development Negative Regulation Of Signaling Regulation Of MAPK Cascade Single Organism Reproductive Process Embryonic Digit Morphogenesis Sex Differentiation Regulation Of Phosphorylation Somitogenesis Reproductive Process Developmental Process Involved In Reproduction Stem Cell Differentiation Embryonic Pattern Specification Cell Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Somite Development Primitive Streak Formation Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorus Metabolic Process Palate Development Regulation Of Embryonic Development Axis Specification Segmentation Mesenchymal Cell Development Negative Regulation Of Phosphorylation Convergent Extension Positive Regulation Of Peptidyl-threonine Phosphorylation Uterus Development Mesenchymal Cell Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Dopaminergic Neuron Differentiation Forebrain Development Central Nervous System Development	Branching Involved In Labyrinthine Layer Morphogenesis Labyrinthine Layer Morphogenesis Embryonic Placenta Morphogenesis Labyrinthine Layer Development In Utero Embryonic Development Embryonic Placenta Development Embryonic Morphogenesis Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Chorionic Trophoblast Cell Proliferation Spemann Organizer Formation Fumarate Metabolic Process Glycerol Biosynthetic Process Aspartate Catabolic Process Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Placenta Development Cellular Response To Insulin Stimulus Morphogenesis Of A Branching Epithelium Glutamate Catabolic Process Morphogenesis Of A Branching Structure Aspartate Metabolic Process Chorionic Trophoblast Cell Differentiation Embryo Development Chorion Development Response To Insulin L-methionine Biosynthetic Process From Methylthioadenosine Cellular Response To Peptide Hormone Stimulus Regulation Of Tight Junction Assembly Cellular Response To Peptide L-methionine Salvage Post-embryonic Camera-type Eye Development Alternative MRNA Splicing, Via Spliceosome Dicarboxylic Acid Catabolic Process Fatty Acid Homeostasis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Methionine Biosynthetic Process Anterior/posterior Axis Specification, Embryo Methionine Metabolic Process Response To Peptide Hormone Cellular Response To Organonitrogen Compound Sulfur Amino Acid Biosynthetic Process Response To Peptide Embryonic Organ Development Glutamate Metabolic Process Apoptotic Process Involved In Morphogenesis
Tagcloud ?		aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring	angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached rims1 scan spanish suffering suggestive t13 unrelated urticaria
Tagcloud (Difference) ?		aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring	angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached rims1 scan spanish suffering suggestive t13 unrelated urticaria
Tagcloud (Intersection) ?