FZD5 and SLC35B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FZD5	SLC35B1
Description		frizzled class receptor 5	solute carrier family 35 member B1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Golgi Apparatus Plasma Membrane Bicellular Tight Junction Cell Surface Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Cell Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity Protein-containing Complex Binding	UDP-galactose Transmembrane Transporter Activity UDP-glucose Transmembrane Transporter Activity ATP:ADP Antiporter Activity Protein Binding Antiporter Activity
	Biological Process	Embryonic Axis Specification Angiogenesis Eye Development Vasculature Development Glandular Epithelial Cell Maturation Positive Regulation Of T Cell Cytokine Production Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Synapse Assembly Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Wnt Signaling Pathway Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis System Development Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Intestinal Epithelial Cell Maturation Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Bicellular Tight Junction Assembly	UDP-glucose Transmembrane Transport ADP Transport ATP Transport Transmembrane Transport UDP-galactose Transmembrane Transport
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		13 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 SLC22A2 SLC35B1 UBTD1 WNT5A WNT7A	20 interacting genes: APP AQP6 ARL13B BNIP3 CCDC107 CD74 CD79A CREB3L1 DRD2 FKBP8 FXYD3 FZD5 FZD7 GPR152 HRH1 MFF PDZK1IP1 PTPN5 VAPA VSIR
Entrez ID		7855	10237
HPRD ID		03427	10237
Ensembl ID		ENSG00000163251	ENSG00000121073
Uniprot IDs		Q13467	P78383
PDB IDs		5URY 5URZ 6O39 6WW2
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Postsynapse Assembly Wnt Signaling Pathway Frizzled Binding Positive Regulation Of Protein Localization To Synapse Toxin Transmembrane Transporter Activity Regulation Of Neuron Projection Development Wnt Signalosome Regulation Of Protein Localization To Cilium Epithelial To Mesenchymal Transition Midbrain Dopaminergic Neuron Differentiation Excitatory Synapse Assembly Secondary Palate Development Presynapse Assembly Establishment Of Cell Polarity Negative Regulation Of Developmental Process Mesenchymal Cell Differentiation Presynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Uterus Development Positive Regulation Of Cell Projection Organization Central Nervous System Neuron Differentiation Regulation Of Axonogenesis Regulation Of JNK Cascade Regulation Of Protein Localization To Synapse Wnt-protein Binding Positive Regulation Of Neuron Projection Development Establishment Or Maintenance Of Cell Polarity Embryonic Axis Specification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Lipid Midbrain Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Dopaminergic Neuron Differentiation Cellular Response To Lipid Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Neuron Projection Organization Regulation Of Protein Localization Postsynapse Organization Presynapse Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Receptor Tyrosine Kinase-like Orphan Receptor Binding Chemoattraction Of Serotonergic Neuron Axon	Membrane Plasma Membrane Visual Learning Regulation Of Autophagy Of Mitochondrion Interneuron Migration From The Subpallium To The Cortex Visual Behavior Signal Transduction Response To Histamine G Protein-coupled Receptor Activity Identical Protein Binding Negative Regulation Of B Cell Apoptotic Process Mitochondrial Envelope Endoplasmic Reticulum Membrane Wnt Receptor Activity Dendrite Protein Trimerization Associative Learning G Protein-coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Uptake Regulation Of B Cell Apoptotic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Mitochondrial Fission Insulin Receptor Binding Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Type II Interferon Production Memory Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Leukocyte Activation Positive Regulation Of Receptor Internalization Wnt-protein Binding Regulation Of Mitochondrial Fission Non-motile Cilium Perikaryon Positive Regulation Of Immune System Process Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Cell Activation Regulation Of Immune Response Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Small Molecule Metabolic Process Learning Cell Activation Frizzled Binding
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