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FZD5 and LZTFL1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
FZD5
LZTFL1
Gene Name
frizzled class receptor 5
leucine zipper transcription factor-like 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Plasma Membrane
Tight Junction
Cell Surface
Integral Component Of Membrane
Clathrin-coated Endocytic Vesicle Membrane
Early Endosome Membrane
Perinuclear Region Of Cytoplasm
Cytosol
BBSome
Molecular Function
G-protein Coupled Receptor Activity
Protein Binding
Wnt-protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Wnt-activated Receptor Activity
Protein Binding
Protein Complex Binding
Identical Protein Binding
Biological Process
Embryonic Axis Specification
Angiogenesis
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Cell Proliferation
Anterior/posterior Axis Specification, Embryo
Neuron Differentiation
Embryonic Camera-type Eye Development
Post-embryonic Camera-type Eye Development
Positive Regulation Of Interferon-gamma Production
T Cell Differentiation In Thymus
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cell Maturation
Spemann Organizer Formation
Canonical Wnt Signaling Pathway
Apoptotic Process Involved In Morphogenesis
Branching Involved In Labyrinthine Layer Morphogenesis
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Labyrinthine Layer Blood Vessel Development
Chorionic Trophoblast Cell Differentiation
Cellular Response To Molecule Of Bacterial Origin
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Chorionic Trophoblast Cell Proliferation
Regulation Of Tight Junction Assembly
Organelle Organization
Establishment Of Protein Localization To Organelle
Negative Regulation Of Protein Localization To Cilium
Negative Regulation Of Protein Localization To Ciliary Membrane
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by Wnt
GPCR ligand binding
Metabolic disorders of biological oxidation enzymes
beta-catenin independent WNT signaling
disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Ca2+ pathway
TCF dependent signaling in response to WNT
regulation of FZD by ubiquitination
RNF mutants show enhanced WNT signaling and proliferation
Asymmetric localization of PCP proteins
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by WNT in cancer
PCP/CE pathway
Class B/2 (Secretin family receptors)
Cargo trafficking to the periciliary membrane
Organelle biogenesis and maintenance
Assembly of the primary cilium
BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
ABI3BP
GOPC
GSK3B
LRP6
LZTFL1
RGS2
ROR2
RPS6KA6
UBTD1
WNT5A
WNT7A
3 interactors:
FZD5
SDCBP
WDYHV1
Entrez ID
7855
54585
HPRD ID
03427
07586
Ensembl ID
ENSG00000163251
ENSG00000163818
Uniprot IDs
Q13467
Q9NQ48
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Embryonic Development
Non-canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Negative Regulation Of Wnt Signaling Pathway
Cartilage Development
Pericardium Morphogenesis
Epithelial To Mesenchymal Transition
Genitalia Development
Negative Regulation Of Signal Transduction
Morphogenesis Of An Epithelial Sheet
Connective Tissue Development
Stem Cell Development
Negative Regulation Of Signaling
Regulation Of MAPK Cascade
Single Organism Reproductive Process
Embryonic Digit Morphogenesis
Sex Differentiation
Regulation Of Phosphorylation
Somitogenesis
Reproductive Process
Developmental Process Involved In Reproduction
Stem Cell Differentiation
Embryonic Pattern Specification
Cell Differentiation
Negative Regulation Of Cardiac Muscle Hypertrophy
Somite Development
Primitive Streak Formation
Negative Regulation Of Muscle Hypertrophy
Regulation Of Phosphorus Metabolic Process
Palate Development
Regulation Of Embryonic Development
Axis Specification
Segmentation
Mesenchymal Cell Development
Negative Regulation Of Phosphorylation
Convergent Extension
Positive Regulation Of Peptidyl-threonine Phosphorylation
Uterus Development
Mesenchymal Cell Differentiation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Dopaminergic Neuron Differentiation
Forebrain Development
Central Nervous System Development
Positive Regulation Of JNK Cascade
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of JNK Cascade
Regulation Of Stress-activated MAPK Cascade
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Regulation Of Chorionic Trophoblast Cell Proliferation
Spemann Organizer Formation
Positive Regulation Of Extracellular Vesicular Exosome Assembly
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Regulation Of Extracellular Vesicular Exosome Assembly
Chorionic Trophoblast Cell Differentiation
Chorion Development
Positive Regulation Of MAPK Cascade
Regulation Of Tight Junction Assembly
Post-embryonic Camera-type Eye Development
Positive Regulation Of Exosomal Secretion
Regulation Of Exosomal Secretion
Branching Involved In Labyrinthine Layer Morphogenesis
Substrate-dependent Cell Migration, Cell Extension
Regulation Of MAPK Cascade
Anterior/posterior Axis Specification, Embryo
Labyrinthine Layer Morphogenesis
Apoptotic Process Involved In Morphogenesis
Dorsal/ventral Axis Specification
Positive Regulation Of Organelle Assembly
Labyrinthine Layer Blood Vessel Development
Positive Regulation Of Intracellular Signal Transduction
Apoptotic Process Involved In Development
Embryonic Placenta Morphogenesis
Positive Regulation Of Phosphorylation
Non-canonical Wnt Signaling Pathway
Cell Differentiation Involved In Embryonic Placenta Development
Cell-cell Signaling
Substrate-dependent Cell Migration
Placenta Blood Vessel Development
Developmental Programmed Cell Death
Developmental Induction
Positive Regulation Of Interferon-gamma Production
Neuron Differentiation
Embryonic Axis Specification
Labyrinthine Layer Development
Embryonic Camera-type Eye Development
Regulation Of Cell Junction Assembly
Positive Regulation Of Exocytosis
Positive Regulation Of Signal Transduction
T Cell Differentiation In Thymus
Anterior/posterior Axis Specification
Regulation Of Phosphorylation
Positive Regulation Of JUN Kinase Activity
Tagcloud
?
aberrant
aberrantly
accessible
bcor
cd127
contributors
covering
cxcl14
fzd8
granulocyte
hes6
hic1
hypermethylated
hypomorphic
island
itpka
leukemic
megakaryocyte
prdm16
preleukemic
progenitors
pu
publicly
robo3
runx1
sca
shortage
tal1
underscoring
Tagcloud (Difference)
?
aberrant
aberrantly
accessible
bcor
cd127
contributors
covering
cxcl14
fzd8
granulocyte
hes6
hic1
hypermethylated
hypomorphic
island
itpka
leukemic
megakaryocyte
prdm16
preleukemic
progenitors
pu
publicly
robo3
runx1
sca
shortage
tal1
underscoring
Tagcloud (Intersection)
?