FZD5 and LZTFL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FZD5	LZTFL1
Description		frizzled class receptor 5	leucine zipper transcription factor like 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Golgi Apparatus Plasma Membrane Bicellular Tight Junction Cell Surface Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Cell Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm	Manchette Cytoplasm Cytosol Cilium
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity Protein-containing Complex Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Embryonic Axis Specification Angiogenesis Eye Development Vasculature Development Glandular Epithelial Cell Maturation Positive Regulation Of T Cell Cytokine Production Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Synapse Assembly Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Wnt Signaling Pathway Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis System Development Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Intestinal Epithelial Cell Maturation Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Bicellular Tight Junction Assembly	Spermatogenesis Flagellated Sperm Motility Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization To Ciliary Membrane
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by RNF43 mutants	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494)	Acne (severe) ( 24927181) COVID-19 (critical illness vs population) ( 33307546) Eosinophil percentage of white cells ( 32888494) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 31604244) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		13 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 SLC22A2 SLC35B1 UBTD1 WNT5A WNT7A	10 interacting genes: EHHADH FZD5 MOB1A NTAQ1 PELI2 PICK1 PSMA1 PSMB1 SDCBP TRIM68
Entrez ID		7855	54585
HPRD ID		03427	07586
Ensembl ID		ENSG00000163251	ENSG00000163818
Uniprot IDs		Q13467	Q9NQ48
PDB IDs		5URY 5URZ 6O39 6WW2
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Postsynapse Assembly Wnt Signaling Pathway Frizzled Binding Positive Regulation Of Protein Localization To Synapse Toxin Transmembrane Transporter Activity Regulation Of Neuron Projection Development Wnt Signalosome Regulation Of Protein Localization To Cilium Epithelial To Mesenchymal Transition Midbrain Dopaminergic Neuron Differentiation Excitatory Synapse Assembly Secondary Palate Development Presynapse Assembly Establishment Of Cell Polarity Negative Regulation Of Developmental Process Mesenchymal Cell Differentiation Presynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Uterus Development Positive Regulation Of Cell Projection Organization Central Nervous System Neuron Differentiation Regulation Of Axonogenesis Regulation Of JNK Cascade Regulation Of Protein Localization To Synapse Wnt-protein Binding Positive Regulation Of Neuron Projection Development Establishment Or Maintenance Of Cell Polarity Embryonic Axis Specification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Lipid Midbrain Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Dopaminergic Neuron Differentiation Cellular Response To Lipid Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Neuron Projection Organization Regulation Of Protein Localization Postsynapse Organization Presynapse Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Receptor Tyrosine Kinase-like Orphan Receptor Binding Chemoattraction Of Serotonergic Neuron Axon	Proteasome Core Complex
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