BIRC5 and CSNK1D

		BIRC5	CSNK1D
Description		baculoviral IAP repeat containing 5	casein kinase 1 delta
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centriole Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex Protein-containing Complex Spindle Midzone Survivin Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Plasma Membrane Cilium Actin Cytoskeleton Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Enzyme Binding Peptidase Inhibitor Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cobalt Ion Binding Protein-folding Chaperone Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Positive Regulation Of Exit From Mitosis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Localization Mitotic Spindle Midzone Assembly Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis	Protein Phosphorylation Endocytosis Microtubule Nucleation Golgi Organization Signal Transduction Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Protein Localization To Golgi Apparatus Regulation Of Circadian Rhythm COPII Vesicle Coating Rhythmic Process Spindle Assembly Protein Localization To Cilium Protein Localization To Centrosome Positive Regulation Of Canonical Wnt Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Non-motile Cilium Assembly Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation	COPII-mediated vesicle transport Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		Reserpine Berberine LY2181308
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		27 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 GAS2L3 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 OGT RAN RASA1 STAMBPL1 XIAP XPO1	43 interacting genes: AKAP9 APP ARFGAP1 ATM BACE1 BRCA1 CCDC14 CDK5 CREB1 CTNNB1 DRICH1 DVL1 DVL3 EVI5 GJA1 HIF1A IKZF4 JPT2 KDR LURAP1 PAK5 PDPK1 PER1 PER2 PER3 PPP1R14A PPP5C PSEN2 PTPRD RAB1A SHANK3 SMAD2 SMAD3 SMURF1 SNAPIN SNCA TP53 TRIM3 TRIM9 YAP1 YWHAZ ZBTB8A ZNF618
Entrez ID		332	1453
HPRD ID		04520	02920
Ensembl ID		ENSG00000089685	ENSG00000141551
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	H7BYT1 P48730
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH 7LBK 7LBO 7LBP 7LBQ 8RUP	3UYS 3UYT 3UZP 4HGT 4HNF 4KB8 4KBA 4KBC 4KBK 4TN6 4TW9 4TWC 5IH4 5IH5 5IH6 5MQV 5OKT 5W4W 6F1W 6F26 6GZM 6HMP 6HMR 6PXN 6PXO 6PXP 6RCG 6RCH 6RU6 6RU7 6RU8 7NZY 7P7F 7P7G 7P7H 7QR9 7QRA 7QRB 8D7M 8D7N 8D7O 8D7P 8IZC 8VXD 8VXF 9B3S
Enriched GO Terms of Interacting Partners?		Chromosome Passenger Complex Cell Division Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Mitotic Spindle Midzone Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Midzone Assembly Regulation Of Metaphase Plate Congression Spindle Microtubule Spindle Regulation Of Cytokinesis Spindle Organization Mitotic Spindle Organization Regulation Of Cell Cycle Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Spindle Midzone Positive Regulation Of Chromosome Segregation Cytoplasm Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Programmed Cell Death Positive Regulation Of Cell Cycle Process Cytosol Fibroblast Apoptotic Process Spindle Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Division Protein Modification Process Chromocenter Positive Regulation Of Cytokinesis Protein-containing Complex Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Neuron Apoptotic Process Transferase Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Cellular Response To Oxygen-containing Compound Mitotic Cell Cycle Mitotic Cytokinesis Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cellular Component Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Transcription Corepressor Binding Enzyme Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Release Response To Radiation Regulation Of Neuron Apoptotic Process Organelle Localization Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Cytoplasm Ubiquitin Protein Ligase Binding I-SMAD Binding Positive Regulation Of Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Membrane Potential Regulation Of Organelle Organization Tissue Development Negative Regulation Of Biosynthetic Process Transcription Coactivator Binding Regulation Of Growth Regulation Of Neurogenesis Positive Regulation Of Multicellular Organismal Process Entrainment Of Circadian Clock By Photoperiod Regulation Of Protein Stability Establishment Of Organelle Localization Developmental Growth Epithelial Tube Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cellular Component Organization Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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