BIRC5 and SSH2

		BIRC5	SSH2
Description		baculoviral IAP repeat containing 5	slingshot protein phosphatase 2
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centriole Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex Protein-containing Complex Spindle Midzone Survivin Complex	Acrosomal Vesicle Extracellular Space Cytoplasm Cytoskeleton Focal Adhesion Cytoplasmic Vesicle Anchoring Junction
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Enzyme Binding Peptidase Inhibitor Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cobalt Ion Binding Protein-folding Chaperone Binding	Actin Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Positive Regulation Of Exit From Mitosis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Localization Mitotic Spindle Midzone Assembly Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis	Protein Dephosphorylation Spermatogenesis Actin Cytoskeleton Organization Cell Differentiation Negative Regulation Of Actin Filament Polymerization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Reserpine Berberine LY2181308
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Coffee consumption (cups per day) ( 25288136) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 30804560) Lymphocyte count ( 32888494 27863252) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		27 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 GAS2L3 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 OGT RAN RASA1 STAMBPL1 XIAP XPO1	2 interacting genes: ACTB CFL1
Entrez ID		332	85464
HPRD ID		04520	09487
Ensembl ID		ENSG00000089685	ENSG00000141298
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	A0A3B3ITS1 B4DK64 F5H527 Q76I76
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH 7LBK 7LBO 7LBP 7LBQ 8RUP	2NT2
Enriched GO Terms of Interacting Partners?		Chromosome Passenger Complex Cell Division Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Mitotic Spindle Midzone Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Midzone Assembly Regulation Of Metaphase Plate Congression Spindle Microtubule Spindle Regulation Of Cytokinesis Spindle Organization Mitotic Spindle Organization Regulation Of Cell Cycle Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Spindle Midzone Positive Regulation Of Chromosome Segregation Cytoplasm Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Programmed Cell Death Positive Regulation Of Cell Cycle Process Cytosol Fibroblast Apoptotic Process Spindle Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Division Protein Modification Process Chromocenter Positive Regulation Of Cytokinesis Protein-containing Complex Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Neuron Apoptotic Process Transferase Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Cellular Response To Oxygen-containing Compound Mitotic Cell Cycle Mitotic Cytokinesis Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Nuclear Matrix Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Survivin Complex Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Kinetochore Vesicle Regulation Of Organelle Organization Regulation Of Norepinephrine Uptake Negative Regulation Of Postsynaptic Density Organization Lamellipodium Cell-cell Junction Transporter Regulator Activity Regulation Of Protein Localization To Cell Leading Edge Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Transepithelial Transport Regulation Of Chromosome Organization Cytoskeleton Positive Regulation Of Exit From Mitosis Cobalt Ion Binding Neural Fold Formation Actin Filament Fragmentation Actin Cytoskeleton Protein Localization To Adherens Junction Dense Body Interphase Microtubule Organizing Center Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Morphogenesis Of A Polarized Epithelium Chromosome Passenger Complex Negative Regulation Of Lamellipodium Assembly Morphogenesis Of An Epithelium Regulation Of Mitotic Cell Cycle Phase Transition Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Cytoskeleton Organization Nitric-oxide Synthase Regulator Activity Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore BBAF Complex
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