BIRC5 and AANAT

		BIRC5	AANAT
Description		baculoviral IAP repeat containing 5	aralkylamine N-acetyltransferase
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centriole Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex Protein-containing Complex Spindle Midzone Survivin Complex	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Enzyme Binding Peptidase Inhibitor Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cobalt Ion Binding Protein-folding Chaperone Binding	Aralkylamine N-acetyltransferase Activity Arylamine N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups 14-3-3 Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Positive Regulation Of Exit From Mitosis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Localization Mitotic Spindle Midzone Assembly Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis	N-terminal Protein Amino Acid Acetylation Circadian Rhythm Response To Light Stimulus Photoperiodism Response To Zinc Ion Melatonin Biosynthetic Process Response To Insulin Response To Cytokine Response To Prostaglandin E Indolalkylamine Biosynthetic Process Response To Copper Ion Rhythmic Process Response To Corticosterone Response To CAMP Response To Calcium Ion Cellular Response To CAMP Response To Peptide
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation	Serotonin and melatonin biosynthesis
Drugs		Reserpine Berberine LY2181308	CoA-S-trimethylene-acetyl-tryptamine CoA-s-acetyl tryptamine CoA-S-acetyl 5-bromotryptamine Cannabidiol Medical Cannabis Nabiximols
Diseases			Delayed sleep phase syndrome
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		27 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 GAS2L3 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 OGT RAN RASA1 STAMBPL1 XIAP XPO1	8 interacting genes: BHLHE40 EIF4E3 F2 GRB10 KRTAP8-1 MDFI PRKACA YWHAZ
Entrez ID		332	15
HPRD ID		04520	02974
Ensembl ID		ENSG00000089685	ENSG00000129673
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	F1T0I5 Q16613
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH 7LBK 7LBO 7LBP 7LBQ 8RUP	6T80
Enriched GO Terms of Interacting Partners?		Chromosome Passenger Complex Cell Division Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Mitotic Spindle Midzone Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Midzone Assembly Regulation Of Metaphase Plate Congression Spindle Microtubule Spindle Regulation Of Cytokinesis Spindle Organization Mitotic Spindle Organization Regulation Of Cell Cycle Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Spindle Midzone Positive Regulation Of Chromosome Segregation Cytoplasm Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Programmed Cell Death Positive Regulation Of Cell Cycle Process Cytosol Fibroblast Apoptotic Process Spindle Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Division Protein Modification Process Chromocenter Positive Regulation Of Cytokinesis Protein-containing Complex Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Neuron Apoptotic Process Transferase Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Cellular Response To Oxygen-containing Compound Mitotic Cell Cycle Mitotic Cytokinesis Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Survivin Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process ERK1 And ERK2 Cascade Protein Sequestering Activity Protein Domain Specific Binding Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Macromolecule Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Negative Regulation Of TOR Signaling TOR Signaling Synaptic Target Recognition Regulation Of TORC1 Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Exit From Mitosis Cobalt Ion Binding Regulation Of Metabolic Process Regulation Of Sequestering Of Calcium Ion Blood Microparticle Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Thrombospondin Receptor Activity Regulation Of Generation Of Precursor Metabolites And Energy Vascular Associated Smooth Muscle Cell Migration Tube Formation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Interphase Microtubule Organizing Center Regulation Of Gene Expression Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Golgi Reassembly MRF Binding Regulation Of TOR Signaling Regulation Of Cell Communication Negative Regulation Of DNA-templated Transcription Chromosome Passenger Complex Regulation Of Signaling Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Localization To Nucleus
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