LAPTM5 and VAMP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LAPTM5	VAMP1
Description		lysosomal protein transmembrane 5	vesicle associated membrane protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Azurophil Granule Membrane Specific Granule Membrane Neuron Projection Synapse Tertiary Granule Membrane
	Molecular Function	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Protein Sequestering Activity	SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of MAPK Cascade Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Golgi To Lysosome Transport Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process	Vesicle Fusion Vesicle-mediated Transport SNARE Complex Assembly
Pathways			Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type G (botG)
Drugs			Botulinum toxin type B
Diseases
GWAS		Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Hip geometry ( 17903296)
Interacting Genes		38 interacting genes: AIG1 ANKRD13A ARLN CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1	37 interacting genes: AQP6 ARL13B BCAP31 CDKN2A CRB3 CREB3L1 CYB5R3 DNAJC5 EBP ELOVL4 ELOVL7 ERGIC3 FAM210B FCER1G GPR152 KASH5 LAPTM5 LMNA REEP4 RETREG3 RNF24 SCN3B SEC11C SGMS2 SLC10A6 SLC30A8 SNAP23 SNAP29 STX1A STX1B STX4 TMEM101 TMEM14B TMEM35A TMX2 VAPA VAPB
Entrez ID		7805	6843
HPRD ID		03280	01716
Ensembl ID		ENSG00000162511	ENSG00000139190
Uniprot IDs		Q13571 Q5TBB8	F5GZV7 P23763
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Clathrin Vesicle Coat Clathrin Binding Ubiquitin Binding Ubiquitin Ligase Complex Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Histone Ubiquitin Ligase Activity Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Protein K48-linked Ubiquitination Symbiont Entry Into Host Cell Catabolic Process Endosome Protein Monoubiquitination Macromolecule Catabolic Process Import Into Cell Endocytosis Biological Process Involved In Interaction With Host Plasma Membrane Protein Tag Activity Receptor Internalization Clathrin-coated Pit Ubiquitin-ubiquitin Ligase Activity Proteasomal Protein Catabolic Process Pulmonary Valve Morphogenesis Clathrin-coated Vesicle Tolerance Induction Proteasome Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Endocardial Cushion Morphogenesis Circulatory System Development Mitochondrial Outer Membrane Membrane Extracellular Exosome Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sprouting Angiogenesis Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-like Protein Ligase Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Organelle Localization By Membrane Tethering Membrane Docking SNARE Complex Membrane Organization Secretion By Cell Exocytosis Organelle Localization Membrane Fusion Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Signal Release Intracellular Protein Localization Endoplasmic Reticulum Vesicle Fusion To Plasma Membrane Vesicle Fusion Organelle Membrane Fusion Vesicle-mediated Transport Vesicle Organization Synaptic Vesicle Membrane Organization Positive Regulation Of Protein Localization To Cell Surface Organelle Fusion Endoplasmic Reticulum Organization Cellular Localization Establishment Of Localization In Cell FFAT Motif Binding Golgi Vesicle Transport Positive Regulation Of Protein Localization COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Synaptic Vesicle Exocytosis Sphingolipid Biosynthetic Process Cytoplasmic Vesicle Regulated Exocytosis Regulation Of Protein Localization To Cell Surface Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid ATP-dependent Protein Binding Endoplasmic Reticulum Localization Regulation Of Protein Localization Fatty Acid Elongation, Saturated Fatty Acid Protein Binding Presynapse Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Regulated Secretory Pathway Azurophil Granule Membrane Host-mediated Activation Of Viral Genome Replication
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