LAPTM5 and EPN3

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAPTM5	EPN3
Description		lysosomal protein transmembrane 5	epsin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endosome Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Protein Sequestering Activity	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding EH Domain Binding
	Biological Process	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of MAPK Cascade Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Golgi To Lysosome Transport Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process	Endocytosis
Pathways
Drugs
Diseases
GWAS		Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Hip index ( 34021172)
Interacting Genes		38 interacting genes: AIG1 ANKRD13A ARLN CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1	11 interacting genes: DAZAP2 FAM168A LAPTM5 LITAF NTAQ1 RNF11 RNF8 RPS27A TRIM26 UBA52 UBC
Entrez ID		7805	55040
HPRD ID		03280	06272
Ensembl ID		ENSG00000162511	ENSG00000049283
Uniprot IDs		Q13571 Q5TBB8	Q9H201
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Clathrin Vesicle Coat Clathrin Binding Ubiquitin Binding Ubiquitin Ligase Complex Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Histone Ubiquitin Ligase Activity Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Protein K48-linked Ubiquitination Symbiont Entry Into Host Cell Catabolic Process Endosome Protein Monoubiquitination Macromolecule Catabolic Process Import Into Cell Endocytosis Biological Process Involved In Interaction With Host Plasma Membrane Protein Tag Activity Receptor Internalization Clathrin-coated Pit Ubiquitin-ubiquitin Ligase Activity Proteasomal Protein Catabolic Process Pulmonary Valve Morphogenesis Clathrin-coated Vesicle Tolerance Induction Proteasome Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Endocardial Cushion Morphogenesis Circulatory System Development Mitochondrial Outer Membrane Membrane Extracellular Exosome Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sprouting Angiogenesis Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-like Protein Ligase Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Ubiquitin Protein Ligase Binding Protein Tag Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Endocytic Vesicle Membrane Protein Modification Process Macromolecule Catabolic Process Endosome Membrane Regulation Of Non-canonical NF-kappaB Signal Transduction Proteolysis WW Domain Binding Vesicle Mitochondrial Outer Membrane Regulation Of Macrophage Cytokine Production Catabolic Process Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Protein-N-terminal Glutamine Amidohydrolase Activity Protein Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Protein Autoubiquitination Ubiquitin Protein Ligase Activity Regulation Of Lysosomal Membrane Permeability Cytoplasmic Side Of Late Endosome Membrane Positive Regulation Of Base-excision Repair Protein-N-terminal Asparagine Amidohydrolase Activity Lysosomal Membrane Cytosolic Ribosome Negative Regulation Of Autophagic Cell Death Ubiquitin Ligase Complex Cytoplasmic Side Of Early Endosome Membrane Regulation Of Base-excision Repair Cytoplasmic Translation Regulation Of Cytokine Production Involved In Immune Response Nucleus Positive Regulation Of DNA Repair Structural Constituent Of Ribosome Response To Insecticide Zinc Ion Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Receptor Catabolic Process
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