LAPTM5 and HERC1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		LAPTM5	HERC1
Description		lysosomal protein transmembrane 5	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Protein Sequestering Activity	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of MAPK Cascade Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Golgi To Lysosome Transport Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process	Autophagy Brain Development Gene Expression Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Corpus Callosum Development Bone Mineralization Neuron Projection Development Bone Remodeling Neuromuscular Process Controlling Balance
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)	A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Glucagon levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Iris characteristics ( 21835309) Reticulocyte fraction of red cells ( 27863252) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		38 interacting genes: AIG1 ANKRD13A ARLN CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1	15 interacting genes: ABL1 BAK1 EP300 FOXP1 LAPTM5 PKM RAF1 RNF11 SOX9 UBC UBE2D2 UBE2D3 UBE2L3 UBE2S USP7
Entrez ID		7805	8925
HPRD ID		03280	06894
Ensembl ID		ENSG00000162511	ENSG00000103657
Uniprot IDs		Q13571 Q5TBB8	Q15751
PDB IDs			4O2W 4QT6
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Clathrin Vesicle Coat Clathrin Binding Ubiquitin Binding Ubiquitin Ligase Complex Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Histone Ubiquitin Ligase Activity Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Protein K48-linked Ubiquitination Symbiont Entry Into Host Cell Catabolic Process Endosome Protein Monoubiquitination Macromolecule Catabolic Process Import Into Cell Endocytosis Biological Process Involved In Interaction With Host Plasma Membrane Protein Tag Activity Receptor Internalization Clathrin-coated Pit Ubiquitin-ubiquitin Ligase Activity Proteasomal Protein Catabolic Process Pulmonary Valve Morphogenesis Clathrin-coated Vesicle Tolerance Induction Proteasome Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Endocardial Cushion Morphogenesis Circulatory System Development Mitochondrial Outer Membrane Membrane Extracellular Exosome Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sprouting Angiogenesis Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-like Protein Ligase Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Metabolic Process Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Programmed Cell Death Cell Death Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Signal Transduction Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein-containing Complex Assembly Protein Metabolic Process Regulation Of Morphogenesis Of An Epithelium Protein-containing Complex Proteolysis Protein Autoubiquitination DNA Damage Response Transferase Activity ERBB Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Pre-mRNA Intronic Binding Regulation Of Primary Metabolic Process Ubiquitin-protein Transferase Activity Apoptotic Process Negative Regulation Of Programmed Cell Death ATP Binding Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Transcription Coactivator Activity Endocrine Pancreas Development Positive Regulation Of Protein Ubiquitination Nucleus Negative Regulation Of Gluconeogenesis Ubiquitin-like Protein Transferase Activity Negative Regulation Of Small Molecule Metabolic Process Cytosol Macromolecule Catabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?