LAPTM5 and KRT7

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		LAPTM5	KRT7
Description		lysosomal protein transmembrane 5	keratin 7
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Protein Sequestering Activity	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of MAPK Cascade Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Golgi To Lysosome Transport Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process	Keratinization Intermediate Filament Organization
Pathways			Keratinization Formation of the cornified envelope Developmental Lineage of Pancreatic Ductal Cells
Drugs			Primaquine Verpasep caltespen
Diseases
GWAS		Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132)
Interacting Genes		38 interacting genes: AIG1 ANKRD13A ARLN CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1	11 interacting genes: ATF7IP EGFR HMGB1 HSPA1A KDM1A KRT13 KRT17 KRT27 LAPTM5 LINC01554 UBE3A
Entrez ID		7805	3855
HPRD ID		03280	01014
Ensembl ID		ENSG00000162511	ENSG00000135480
Uniprot IDs		Q13571 Q5TBB8	P08729
PDB IDs			4XIF
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Clathrin Vesicle Coat Clathrin Binding Ubiquitin Binding Ubiquitin Ligase Complex Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Histone Ubiquitin Ligase Activity Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Protein K48-linked Ubiquitination Symbiont Entry Into Host Cell Catabolic Process Endosome Protein Monoubiquitination Macromolecule Catabolic Process Import Into Cell Endocytosis Biological Process Involved In Interaction With Host Plasma Membrane Protein Tag Activity Receptor Internalization Clathrin-coated Pit Ubiquitin-ubiquitin Ligase Activity Proteasomal Protein Catabolic Process Pulmonary Valve Morphogenesis Clathrin-coated Vesicle Tolerance Induction Proteasome Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Endocardial Cushion Morphogenesis Circulatory System Development Mitochondrial Outer Membrane Membrane Extracellular Exosome Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sprouting Angiogenesis Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-like Protein Ligase Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Morphogenesis Of An Epithelium Tissue Morphogenesis Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Transcription Corepressor Activity Keratinization Hair Cycle Process Regulation Of Post-translational Protein Modification Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Positive Regulation Of Biosynthetic Process Hair Follicle Morphogenesis Regulation Of Ubiquitin-dependent Protein Catabolic Process Structural Molecule Activity Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of DNA Repair Multivesicular Body, Internal Vesicle Lumen Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Response To Steroid Hormone Positive Regulation Of Myeloid Progenitor Cell Differentiation Intermediate Filament Polymerization Cytoskeleton Organization Intermediate Filament Cytoskeleton Sperm Entry Positive Regulation Of Golgi Lumen Acidification Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
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