ZNF224 and PRMT5

Number of citations of the paper that reports this interaction (PMID 19741270)
9

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ZNF224	PRMT5
Gene Name		zinc finger protein 224	protein arginine methyltransferase 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcriptional Repressor Complex Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation
Pathways		Generic Transcription Pathway	Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814)
Protein-Protein Interactions		2 interactors: MTUS2 PRMT5	67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP
Entrez ID		7767	10419
HPRD ID		06094	04955
Ensembl ID		ENSG00000267680	ENSG00000100462
Uniprot IDs		Q9NZL3	O14744
PDB IDs		2ELY 2ELZ 2EM0 2EM6 2EM7 2EM8 2EM9 2EN1 2EN8 2ENA 2ENC 2EOQ 2EOR 2EQ4 2YSP 2YTH	4GQB
Enriched GO Terms of Interacting Partners?		Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Histone H4-R3 Methylation Endothelial Cell Activation Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Spliceosomal SnRNP Assembly Circadian Regulation Of Gene Expression Histone Methylation Regulation Of Mitotic Nuclear Division Protein Methylation Circadian Rhythm Ribonucleoprotein Complex Assembly MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions	Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		aging alleles anthropometric assessments cetp collect comt cr1 create enable enjoy foxo3 genetics hoped links longevity modern neuroprotection neuroprotective nonagenarians notable participant pck picalm postulated represented sociodemographic taqman tomm40	acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Difference) ?		aging alleles anthropometric assessments cetp collect comt cr1 create enable enjoy foxo3 genetics hoped links longevity modern neuroprotection neuroprotective nonagenarians notable participant pck picalm postulated represented sociodemographic taqman tomm40	acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Intersection) ?