ZMYM2 and ZBTB3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZMYM2	ZBTB3
Description		zinc finger MYM-type containing 2	zinc finger and BTB domain containing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol PML Body	Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of DNA-templated Transcription	Regulation Of Transcription By RNA Polymerase II
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Adult body size ( 32376654) Facial emotion recognition (happy faces) ( 28608620) Hand grip strength ( 29691431)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		32 interacting genes: CEBPE CRBN CREB1 CREBBP ERG FBXL17 FOXP1 FOXP2 FOXP4 FUS GMCL1 HNRNPA2B1 HNRNPH3 IKZF3 PAICS PTBP1 SFPQ SKIL SLC19A4P SMAD3 SMAD4 SNIP1 SREBF2 SUMO1 SUMO2 SUMO3 TSC22D2 UBE2A UBE2I UBTF ZBTB3 ZNF512B	24 interacting genes: ANKRD2 AP1M1 BIN1 EIF5B FOXM1 GATA4 GTF2A1L IKBKG IRF6 JADE2 LEF1 MYO15B NR3C1 PKNOX1 PPARG PROX1 SKIL SMAD3 SMYD1 SSX3 SUPT5H THRA ZMYM2 ZNF556
Entrez ID		7750	79842
HPRD ID		03745	15693
Ensembl ID		ENSG00000121741	ENSG00000185670
Uniprot IDs		A8K126 Q9UBW7	A0A6E1W9L1
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding PML Body Chromatin Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Protein Tag Activity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Regulation Of MiRNA Transcription Ubiquitin-like Protein Ligase Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Metabolic Process MiRNA Processing Small Protein Activating Enzyme Binding Transforming Growth Factor Beta Receptor Signaling Pathway Identical Protein Binding	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Epithelial Cell Differentiation Animal Organ Development Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Domain Binding Positive Regulation Of Biosynthetic Process DNA-templated Transcription Myeloid Cell Differentiation Cell Differentiation DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Regulator Complex Gland Development Transdifferentiation LBD Domain Binding Chromatin Binding Tube Morphogenesis
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