CACNA1C and RYR2

  • Number of citations of the paper that reports this interaction (PubMedID 11576544)
  • 0
  • Data Source:
  • HPRD (in vitro)

CACNA1C

RYR2

Description calcium voltage-gated channel subunit alpha1 C ryanodine receptor 2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acoustic startle blink response ( 25387708)
  • Adult body size ( 32376654)
  • Adventurousness ( 30643258)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Aortic root size ( 28394258)
  • Appendicular lean mass ( 33097823)
  • Atypical femoral fracture in phosphonate treatment ( 31006051)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
  • Bipolar disorder ( 18711365 34002096 33263727 31043756 28072414 20351715)
  • Bipolar disorder or major depressive disorder ( 20351715)
  • Bipolar I disorder ( 31043756)
  • Broad depression or bipolar disorder ( 30626913)
  • Broad depression or schizophrenia ( 30626913)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Diastolic blood pressure ( 30224653)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244)
  • Fractional exhaled nitric oxide (childhood) ( 24315451)
  • General risk tolerance (MTAG) ( 30643258)
  • Heel bone mineral density ( 28869591 30598549)
  • Hematocrit ( 32888494 27863252)
  • Hemoglobin ( 32888494)
  • Hemoglobin concentration ( 27863252)
  • Lumbar spine bone mineral density (integral) ( 27476799)
  • Lumbar spine bone mineral density (trabecular) ( 27476799)
  • Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Perceived intensity of aspartame ( 31005972)
  • Platelet count ( 32888494)
  • Platelet distribution width ( 32888494)
  • Plateletcrit ( 32888494)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603)
  • Psychosis proneness (hypomanic personality scale) ( 28525603)
  • Red blood cell count ( 27863252 32888494 29403010)
  • Red blood cell traits ( 23222517)
  • Response to olanzapine in schizophrenia ( 29503163)
  • Resting heart rate ( 27798624 29769521)
  • Schizophrenia ( 23974872 25056061 28991256 29483656 21926974 22688191 30285260)
  • Schizophrenia or bipolar disorder ( 24280982)
  • Sensorimotor dexterity ( 31596458)
  • Short-term memory (digit-span task) ( 30741946)
  • Sleep quality ( 23728906)
  • Warfarin maintenance dose ( 18535201)
  • Acute lymphoblastic leukemia (childhood) ( 19684603)
  • Bipolar disorder and eating disorder ( 26433762)
  • Cerivastatin-induced rhabdomyolysis ( 21386754)
  • cognitive impairment (MMSE score) in Parkinson’s disease ( 33613413)
  • Exercise treadmill test traits ( 17903301)
  • General risk tolerance (MTAG) ( 30643258)
  • Hippocampal volume ( 31530798)
  • Hypertension ( 17554300)
  • Lipid traits ( 24386095 30576415)
  • Lung function (FEV1) ( 30061609)
  • Lung function (FVC) ( 30061609)
  • Metabolite levels ( 23823483)
  • Obesity-related traits ( 23251661)
  • Postoperative stroke after cardiac surgery ( 30678657)
  • PR interval ( 32439900)
  • Response to taxane treatment (docetaxel) ( 23006423)
  • Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes 25 interacting genes: ACTN2 ANKRD35 BSG C18orf32 CABP1 CACNB3 COPS5 DNAJA3 EFEMP1 FHL2 GNB1 HDAC4 IFT88 NUP133 PCBD1 PICK1 PPM1A PRKACA RIC3 RIMS1 RYR2 SRI SRRT TNIP2 VCP 21 interacting genes: AKAP6 ALB CACNA1C CACNA1D FKBP1B HOMER1 HSPB2 ITPR1 JPH3 JPH4 KCNN4 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI UBE2C
Entrez ID 775 6262
HPRD ID 00246 01619
Ensembl ID ENSG00000151067 ENSG00000198626
Uniprot IDs A0A0A0MR67 A0A0A0MSA1 A0A804HI37 A0A804HIJ8 A0A804HJB6 A0A804HKC4 E9PDI6 F5H522 Q13936 Q59GU3 Q5V9X9 Q92736
PDB IDs 1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ 5V2P 5V2Q 6C0A 6DAD 6DAE 6DAF 6U39 6U3A 6U3B 6U3D 7L8V 8EOG 8EOI 8FD7 8FHS 8HLP 8HMA 8HMB 8UKO 8UKP 8WE6 8WE7 8WE8 8WE9 8WEA 4JKQ 6Y4O 6Y4P 7KL5 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 8UQ2 8UQ3 8UQ4 8UQ5 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?