PMM1 and RAB6B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PMM1	RAB6B
Description		phosphomannomutase 1	RAB6B, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Cytosol Neuronal Cell Body	Golgi Membrane Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Membrane Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	Phosphomannomutase Activity Protein Binding Isomerase Activity Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding
	Biological Process	Mannose Metabolic Process Protein N-linked Glycosylation GDP-mannose Biosynthetic Process Nucleoside Phosphate Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Neuron Projection Development Retrograde Transport, Endosome To Golgi Protein Localization To Golgi Membrane
Pathways		Synthesis of GDP-mannose	COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)	Blood protein levels ( 30072576) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		5 interacting genes: CACNA1A MFHAS1 RAB6A RAB6B RCHY1	13 interacting genes: ACVR1 BICD2 BMPR1B COG6 ERC1 KIF20A LNX2 MEOX2 PMM1 RABGAP1 SH2B2 SMAD1 TGFBR1
Entrez ID		5372	51560
HPRD ID		03473	11474
Ensembl ID		ENSG00000100417	ENSG00000154917
Uniprot IDs		Q92871	Q9NRW1
PDB IDs		2FUC 2FUE 6CFR 6CFS 6CFT 6CFU 6CFV	2E9S 2FE4 2FFQ
Enriched GO Terms of Interacting Partners?		Protein Localization To Golgi Membrane Myosin V Binding Protein Localization To Golgi Apparatus Intra-Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum GTP Binding Peptidyl-cysteine Methylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosolic Transport Retrograde Transport, Endosome To Golgi Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Autoubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process VCB Complex Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Minus-end-directed Organelle Transport Along Microtubule NEDD8 Ligase Activity Cul7-RING Ubiquitin Ligase Complex Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal NEDD8 Transferase Activity Error-free Translesion Synthesis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Autoubiquitination Regulation Of Protein Ubiquitination Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Protein Catabolic Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Post-translational Protein Modification Negative Regulation Of Response To Oxidative Stress Ubiquitin-protein Transferase Activity Endosomal Transport Endomembrane System Golgi Vesicle Transport Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Negative Regulation Of Mitophagy Transcription-coupled Nucleotide-excision Repair High Voltage-gated Calcium Channel Activity Protein Localization To Membrane Ubiquitin Protein Ligase Binding GTPase Activity Ciliary Basal Body Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Toll-like Receptor 4 Signaling Pathway	Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type I SMAD Binding BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Activin Binding BMP Signaling Pathway Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Response To Growth Factor Pharyngeal System Development Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Binding Osteoblast Differentiation Regulation Of Osteoblast Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Cell Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Growth Factor Binding Endocardial Cushion Cell Fate Commitment Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Positive Regulation Of Ossification Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regionalization Dorsal/ventral Pattern Formation Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Embryonic Heart Tube Morphogenesis Bone Development Homomeric SMAD Protein Complex Phosphomannomutase Activity Vascular Endothelial Cell Proliferation
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