TRIM26 and UBE2D3

Number of citations of the paper that reports this interaction (PubMedID 34017102)
46

Data Source:
BioGRID (pull down)

		TRIM26	UBE2D3
Description		tripartite motif containing 26	ubiquitin conjugating enzyme E2 D3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Immune System Process Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Suppression Of Symbiont Invasion Protein K11-linked Ubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Interferon gamma signaling	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) General cognitive ability ( 29844566) Hematocrit ( 32888494) LDL cholesterol levels ( 32203549) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 22883433 30285260 21926974) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)	Alanine aminotransferase levels ( 33547301) Asthma and attention deficit hyperactivity disorder ( 31619474) Diastolic blood pressure ( 30224653) Shoulder impingement or rotator cuff tear ( 33482370)
Interacting Genes		32 interacting genes: BEND7 BIVM CEBPD CTNNB1 DDX41 EPN2 EPN3 INCA1 IRF3 LMNA MACROH2A1 MAGEA6 MECOM MIR138-2 MIR18B MNAT1 OTUB2 PHF7 RABEP1 RNF126 SOX2 SUMO2 TAB1 THAP1 TLE5 TRIM41 UBC UBE2D1 UBE2D2 UBE2D3 USP5 ZEB1	223 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CRBN CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO4 FBXO7 FBXW10 FBXW11 FBXW8 FOCAD FZR1 H2AC4 HDAC6 HECTD1 HECTD3 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A IKBKG ITCH KAT2B KDM1B KLHL3 LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP OTUB1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PPP4C PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF103 RNF111 RNF113A RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF26 RNF31 RNF34 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNF598 ZNRF1 ZNRF2 ZNRF4
Entrez ID		7726	7323
HPRD ID		02901	04269
Ensembl ID		ENSG00000234127	ENSG00000109332
Uniprot IDs		A0A024RCP3 Q12899	D6RAH7 P61077
PDB IDs			1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV 7LYB 8AMS 8GRQ 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process CGAS/STING Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Epithelial Cell Differentiation Clathrin Vesicle Coat Regulation Of RNA Metabolic Process Protein Monoubiquitination Protein Polyubiquitination Regulation Of Epithelial Cell Differentiation Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Ubiquitin Protein Ligase Activity Regulation Of Sister Chromatid Cohesion Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Type I Interferon Production Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of Cell Communication	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Response To Stress Cellular Response To Stress Protein Monoubiquitination Regulation Of Signal Transduction Ubiquitin-ubiquitin Ligase Activity Regulation Of Signaling Regulation Of Post-translational Protein Modification Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Positive Regulation Of Catabolic Process Ubiquitin Binding Cytosol Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction DNA Damage Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Immune System Process Negative Regulation Of Signaling
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