TRIM26 and MACROH2A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM26	MACROH2A1
Description		tripartite motif containing 26	macroH2A.1 histone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleosome Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Extracellular Exosome Site Of DNA Damage
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RDNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding Poly-ADP-D-ribose Modification-dependent Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Immune System Process Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Suppression Of Symbiont Invasion Protein K11-linked Ubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Oxidative Phosphorylation DNA Repair Chromatin Organization Nucleosome Assembly Dosage Compensation By Inactivation Of X Chromosome Regulation Of Lipid Metabolic Process Heterochromatin Formation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Epigenetic Regulation Of Gene Expression Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Regulation Of RDNA Heterochromatin Formation Protein Poly-ADP-ribosylation Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of NAD Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) General cognitive ability ( 29844566) Hematocrit ( 32888494) LDL cholesterol levels ( 32203549) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 22883433 30285260 21926974) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)
Interacting Genes		32 interacting genes: BEND7 BIVM CEBPD CTNNB1 DDX41 EPN2 EPN3 INCA1 IRF3 LMNA MACROH2A1 MAGEA6 MECOM MIR138-2 MIR18B MNAT1 OTUB2 PHF7 RABEP1 RNF126 SOX2 SUMO2 TAB1 THAP1 TLE5 TRIM41 UBC UBE2D1 UBE2D2 UBE2D3 USP5 ZEB1	21 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 CYSRT1 ERICH2 FAM133A H2BC15 KRTAP10-8 NKAPD1 PARP1 RNF168 SPOP SREK1IP1 SRPK1 TRAF2 TRIM26 TRIM59 VCX2 ZNF622
Entrez ID		7726	9555
HPRD ID		02901	13624
Ensembl ID		ENSG00000234127	ENSG00000113648
Uniprot IDs		A0A024RCP3 Q12899	A0A994J4J7 B4DJC3 O75367
PDB IDs			1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC 7D3Y
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process CGAS/STING Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Epithelial Cell Differentiation Clathrin Vesicle Coat Regulation Of RNA Metabolic Process Protein Monoubiquitination Protein Polyubiquitination Regulation Of Epithelial Cell Differentiation Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Ubiquitin Protein Ligase Activity Regulation Of Sister Chromatid Cohesion Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Type I Interferon Production Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of Cell Communication	Histone H2AK127 Ubiquitin Ligase Activity Protein Polyubiquitination Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Chromatin Organization Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification Process Chromatin Remodeling Ubiquitin Ligase Complex BRCA1-B Complex Protein Modification By Small Protein Conjugation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Ionizing Radiation Zinc Ion Binding BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Intrinsic Apoptotic Signaling Pathway Innate Immune Response Identical Protein Binding Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of RNA Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair DNA Recombination Protein Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Site Of Double-strand Break Chromatin Binding Ubiquitin-protein Transferase Activity DNA Damage Checkpoint Signaling Response To Other Organism Negative Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Cell Cycle Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA Damage Checkpoint Host-mediated Suppression Of Symbiont Invasion Regulation Of Cellular Response To Stress DNA Repair-dependent Chromatin Remodeling Ubiquitin Protein Ligase Binding Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Programmed Cell Death Protein K6-linked Ubiquitination Regulation Of Phosphorus Metabolic Process
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