VEZF1 and MLLT10

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VEZF1	MLLT10
Name		vascular endothelial zinc finger 1	MLLT10 histone lysine methyltransferase DOT1L cofactor
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Histone Binding Metal Ion Binding
	Biological Process	Angiogenesis Endothelial Cell Development Regulation Of Transcription By RNA Polymerase II Cellular Defense Response Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
GWAS		Metabolite levels ( 23823483 )	Adult body size ( 32376654 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 23535729 ) Epithelial ovarian cancer ( 25581431 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) Gallstone disease ( 30504769 ) Hand grip strength ( 29691431 ) Lateral ventricular volume in normal aging ( 30258056 ) Meningioma ( 21804547 ) Metabolic syndrome ( 31589552 ) Multiple sclerosis ( 31604244 ) Multisite chronic pain ( 31194737 33830993 ) Oily fish consumption ( 32066663 ) Ovarian cancer ( 23535730 ) Pork consumption ( 32066663 ) Raw vegetable consumption ( 32066663 ) Smoking initiation ( 33082346 ) Subcutaneous adipose tissue ( 26480920 ) Urinary albumin-to-creatinine ratio ( 31630189 ) Urinary sodium excretion ( 31409800 ) Walking pace ( 33128006 )
Interacting Genes		65 interacting genes: AGR2 ATXN7L1 BANP C10orf55 CEACAM6 CEP76 DAZAP2 EHMT2 FAM153B FAM168B FOSB FSD2 GOLGA6L9 GPSM1 HIVEP1 HOMEZ HSF2BP HSPB2 HSPB2-C11orf52 INCA1 KCTD7 KRT40 KRTAP10-8 KRTAP19-5 KRTAP8-1 LASP1 LCN2 LHX3 LMO2 LZTS2 MEIS3 MEOX2 MLLT10 MSX2 NCKIPSD NFYA NRF1 OGT PFDN5 PICK1 PLAGL2 POGZ POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RUBCN SF3A2 SOX13 SP4 SPAG16 TLE5 TRAF1 TRAF2 TRIM27 TSC1 UBE2I VBP1 VPS52 WWOX ZMYND12	16 interacting genes: DISC1 DOT1L EPS15 FOXI1 HNF1B HPCA MLLT1 NCALD NDEL1 POU2F1 POU6F2 RBPMS RGPD5 SS18 VEZF1 YEATS4
Entrez ID		7716	8028
HPRD ID		08416	03874
Ensembl ID		ENSG00000136451	ENSG00000078403
Uniprot IDs		J3QSH4 Q14119	P55197 Q59EQ6
PDB IDs		Not available	5DAG 5DAH 6CKN 6CKO 6JN2 7MJU
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Identical Protein Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Prefoldin Complex Phosphatidylinositol 3-kinase Inhibitor Activity Negative Regulation Of Macroautophagy Intermediate Filament Negative Regulation Of Wnt Signaling Pathway	Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cerebral Cortex Radially Oriented Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Cerebral Cortex Cell Migration Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Electrical Stimulus Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Telencephalon Cell Migration Forebrain Cell Migration Kinesin Complex Alpha-tubulin Binding Histone H3K79 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Response To Ketamine Hepatoblast Differentiation Regulation Of Pronephros Size Histone H3K18ac Reader Activity Neurofilament Cytoskeleton Regulation Of Stem Cell Population Maintenance Transcription Coactivator Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Histone H3K27ac Reader Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of Gene Expression