ZNF135 and RAP1B

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		ZNF135	RAP1B
Name		zinc finger protein 135	RAP1B, member of RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Morphogenesis	Signal Transduction Small GTPase-mediated Signal Transduction Cell Population Proliferation Calcium-ion Regulated Exocytosis Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Localization In Cell Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Modification Of Postsynaptic Structure Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Generic Transcription Pathway	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants
GWAS		No GWAS studies recorded	Femoral neck bone mineral density ( 32239398 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) HDL cholesterol levels in HIV infection ( 33109212 ) White blood cell count ( 20139978 )
Interacting Genes		10 interacting genes: ANKS1A ANXA7 CDKN1A GADD45A GSK3B LMO4 RAP1B RCC1 SCNM1 WWOX	31 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 DVL2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		7694	5908
HPRD ID		07242	01546
Ensembl ID		ENSG00000176293	ENSG00000127314
Uniprot IDs		B4DLZ7 P52742 Q8N9M3	B7ZAY2 P61224
PDB IDs		Not available	3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4 6UZK 7C7I 7C7J 8SU8 8T09 8T7V
GO Terms Enriched among Interactors		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Cell Cycle Phase Transition Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Cellular Developmental Process Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Apoptotic Signaling Pathway Cellular Response To Ionizing Radiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Protein Phosphorylation Signal Transduction By P53 Class Mediator Regulation Of Phosphorylation Regulation Of Protein-containing Complex Assembly Ventral Spinal Cord Interneuron Differentiation Intracellular Signal Transduction Negative Regulation Of Phosphorylation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion Extrinsic Apoptotic Signaling Pathway Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Kinase Activity Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein-containing Complex Assembly RNA Polymerase II Transcription Regulator Complex Sulfate Binding Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Response To Ionizing Radiation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Phosphate Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Signal Transduction In Response To DNA Damage Negative Regulation Of Protein Metabolic Process	Ras Protein Signal Transduction Regulation Of Carbohydrate Catabolic Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Regulation Of Purine Nucleotide Metabolic Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Small GTPase-mediated Signal Transduction Regulation Of NADP Metabolic Process Regulation Of JNK Cascade Regulation Of Primary Metabolic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Lipoprotein Transport Cellular Response To Catecholamine Stimulus Response To CAMP Transition Metal Ion Binding Response To Catecholamine Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Glycolytic Process Regulation Of Translation Positive Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Cell Death Programmed Cell Death Response To Radiation Cellular Response To Gamma Radiation Glucose Catabolic Process Signal Transduction Response To Ethanol Regulation Of Cell Communication