ZNF131 and KPNA6

Number of citations of the paper that reports this interaction (PubMedID 17306895)
0

Data Source:
BioGRID (pull down)

		ZNF131	KPNA6
Description		zinc finger protein 131	karyopherin subunit alpha 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane NLS-dependent Protein Nuclear Import Complex Host Cell
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Positive Regulation Of Transcription By RNA Polymerase II	Transcription By RNA Polymerase II Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle
Pathways		SUMOylation of transcription cofactors	Assembly of the ORC complex at the origin of replication
Drugs
Diseases
GWAS		Body mass index ( 25673413) Mean corpuscular hemoglobin concentration ( 32888494) Menarche (age at onset) ( 25231870)	Body mass index ( 26426971)
Interacting Genes		8 interacting genes: EMSY FHL2 HSPB1 KPNA2 KPNA3 KPNA6 MORN4 PIP4K2B	35 interacting genes: ANP32A ARNT BRCA1 CDKN1B CREBBP CSE1L DCPS DYRK1A EPAS1 FAM90A1 FRG1BP GEMIN2 HIF1A IL1A JRK KAT5 KEAP1 KPNB1 LMNA LMNB1 MAGED1 NMNAT1 NOP2 OGT POLR3C POM121 POU6F2 RAC1 RELB SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131
Entrez ID		7690	23633
HPRD ID		07239	09465
Ensembl ID		ENSG00000172262	ENSG00000025800
Uniprot IDs		P52739	O60684
PDB IDs			4UAD 7RHT
Enriched GO Terms of Interacting Partners?		Viral Penetration Into Host Nucleus Intracellular Transport Of Virus Host Cell NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Protein Import Into Nucleus Import Into Nucleus Viral Process Intracellular Protein Transport Positive Regulation Of Viral Life Cycle Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of Viral Process Establishment Of Protein Localization To Organelle Negative Regulation Of Protein Kinase C Signaling Protein Transport Atrial Cardiac Muscle Cell Development Positive Regulation Of Cytokine Production Protein Kinase C Inhibitor Activity Intracellular Transport Regulation Of Viral Life Cycle 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process 1-phosphatidylinositol-5-phosphate 4-kinase Activity Z Disc Establishment Of Protein Localization Regulation Of Viral Process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Metabolic Process Regulation Of Protein Kinase C Signaling Protein Localization To Organelle Nucleoplasm Cellular Localization Establishment Of Localization In Cell 1-phosphatidylinositol-4-phosphate 5-kinase Activity Actin-based Cell Projection Anterograde Axonal Protein Transport Ventricular Cardiac Muscle Cell Development Regulation Of Cytokine Production Nucleus Intracellular Protein Localization Phosphatidylinositol Kinase Activity Protein Transport Along Microtubule Contractile Muscle Fiber Heart Trabecula Formation Positive Regulation Of Endothelial Cell Chemotaxis Autophagosome-lysosome Fusion Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Nucleoplasm Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Stress P53 Binding Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Cytokine Production Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Erythrocyte Differentiation Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Transcription Coactivator Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Erythrocyte Differentiation Regulation Of Programmed Cell Death Transcription Coactivator Binding
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