ZNF131 and EMSY

Number of citations: 31 (PubMedID 26841866)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ZNF131	EMSY
Name		zinc finger protein 131	EMSY transcriptional repressor, BRCA2 interacting
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Positive Regulation Of Transcription By RNA Polymerase II	DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response
Pathways		SUMOylation of transcription cofactors	None
GWAS		Body mass index ( 25673413 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Menarche (age at onset) ( 25231870 )	Allergic rhinitis ( 31361310 ) Asthma ( 29273806 31361310 31959851 34103634 ) Asthma (adult onset) ( 31036433 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Eczema ( 31361310 ) Eosinophil count ( 29403010 ) Eosinophilic esophagitis ( 34506852 ) Type 1 diabetes ( 34012112 )
Interacting Genes		8 interacting genes: EMSY FHL2 HSPB1 KPNA2 KPNA3 KPNA6 MORN4 PIP4K2B	14 interacting genes: AIDA AKT1 BRCA2 CBX1 CLVS2 DDIT3 DISC1 GET3 H3-4 LIX1 PSMA1 ZMYND11 ZNF131 ZNF646
Entrez ID		7690	56946
HPRD ID		07239	10544
Ensembl ID		ENSG00000172262	ENSG00000158636
Uniprot IDs		P52739	Q7Z589
PDB IDs		Not available	1UTU 1UZ3 2FMM
GO Terms Enriched among Interactors		Viral Penetration Into Host Nucleus Intracellular Transport Of Virus Host Cell NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Protein Import Into Nucleus Import Into Nucleus Viral Process Intracellular Protein Transport Positive Regulation Of Viral Life Cycle Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of Viral Process Establishment Of Protein Localization To Organelle Negative Regulation Of Protein Kinase C Signaling Protein Transport Atrial Cardiac Muscle Cell Development Positive Regulation Of Cytokine Production Protein Kinase C Inhibitor Activity Intracellular Transport Regulation Of Viral Life Cycle 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process 1-phosphatidylinositol-5-phosphate 4-kinase Activity Z Disc Establishment Of Protein Localization Regulation Of Viral Process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Metabolic Process Regulation Of Protein Kinase C Signaling Protein Localization To Organelle Nucleoplasm Cellular Localization Establishment Of Localization In Cell 1-phosphatidylinositol-4-phosphate 5-kinase Activity Actin-based Cell Projection Anterograde Axonal Protein Transport Ventricular Cardiac Muscle Cell Development Regulation Of Cytokine Production Nucleus Intracellular Protein Localization Phosphatidylinositol Kinase Activity Protein Transport Along Microtubule Contractile Muscle Fiber Heart Trabecula Formation Positive Regulation Of Endothelial Cell Chemotaxis Autophagosome-lysosome Fusion Negative Regulation Of Calcineurin-NFAT Signaling Cascade	PERK-mediated Unfolded Protein Response