ZNF131 and PIP4K2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF131	PIP4K2B
Description		zinc finger protein 131	phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Nucleotide Binding Protein Binding ATP Binding GTP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Protein Homodimerization Activity Phosphatidylinositol Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Positive Regulation Of Transcription By RNA Polymerase II	Lipid Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways		SUMOylation of transcription cofactors	Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs			Fostamatinib
Diseases
GWAS		Body mass index ( 25673413) Mean corpuscular hemoglobin concentration ( 32888494) Menarche (age at onset) ( 25231870)	Appendicular lean mass ( 33097823) Height ( 20881960 28552196 31562340)
Interacting Genes		8 interacting genes: EMSY FHL2 HSPB1 KPNA2 KPNA3 KPNA6 MORN4 PIP4K2B	17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131
Entrez ID		7690	8396
HPRD ID		07239	04463
Ensembl ID		ENSG00000172262	ENSG00000276293
Uniprot IDs		P52739	P78356
PDB IDs			1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H 7EM1 7EM2 7EM3 7EM4 7EM5 7EM6 7EM7 7EM8 7N80 7N81
Enriched GO Terms of Interacting Partners?		Viral Penetration Into Host Nucleus Intracellular Transport Of Virus Host Cell NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Protein Import Into Nucleus Import Into Nucleus Viral Process Intracellular Protein Transport Positive Regulation Of Viral Life Cycle Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of Viral Process Establishment Of Protein Localization To Organelle Negative Regulation Of Protein Kinase C Signaling Protein Transport Atrial Cardiac Muscle Cell Development Positive Regulation Of Cytokine Production Protein Kinase C Inhibitor Activity Intracellular Transport Regulation Of Viral Life Cycle 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process 1-phosphatidylinositol-5-phosphate 4-kinase Activity Z Disc Establishment Of Protein Localization Regulation Of Viral Process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Metabolic Process Regulation Of Protein Kinase C Signaling Protein Localization To Organelle Nucleoplasm Cellular Localization Establishment Of Localization In Cell 1-phosphatidylinositol-4-phosphate 5-kinase Activity Actin-based Cell Projection Anterograde Axonal Protein Transport Ventricular Cardiac Muscle Cell Development Regulation Of Cytokine Production Nucleus Intracellular Protein Localization Phosphatidylinositol Kinase Activity Protein Transport Along Microtubule Contractile Muscle Fiber Heart Trabecula Formation Positive Regulation Of Endothelial Cell Chemotaxis Autophagosome-lysosome Fusion Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Nucleus Negative Regulation Of DNA Recombination Nucleoplasm Cajal Body Regulation Of Primary Metabolic Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Identical Protein Binding Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process DNA Metabolic Process DNA Damage Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Kynureninase Activity Telomere-telomerase Complex Assembly Regulation Of DNA Metabolic Process Response To Stress Positive Regulation Of Immunoglobulin Production Double-strand Break Repair Via Nonhomologous End Joining DNA Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Type I Hypersensitivity B Cell Affinity Maturation Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Response To Vitamin B6 Nuclear Proteasome Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Immunoglobulin Production Regulation Of Metabolic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Macromolecule Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase CK2 Complex
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