CA8 and SPDL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CA8	SPDL1
Description		carbonic anhydrase 8	spindle apparatus coiled-coil protein 1
Image
GO Annotations	Cellular Component	Cytoplasm	Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Enzyme Binding Kinetochore Binding
	Biological Process	Positive Regulation Of Calcium-mediated Signaling	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Chromosome Alignment Mitotic Spindle Assembly Checkpoint Signaling Cell Migration Protein Localization To Kinetochore Cell Division
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Zonisamide
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) High myopia ( 33830181) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 29483656 28991256 30285260 25056061) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Bipolar disorder x sex interaction ( 34099189)
Interacting Genes		14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3	10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45
Entrez ID		767	54908
HPRD ID		00266	08623
Ensembl ID		ENSG00000178538	ENSG00000040275
Uniprot IDs		P35219	Q96EA4
PDB IDs		2W2J	8ARF
Enriched GO Terms of Interacting Partners?
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