SPDL1 and USP45

Number of citations of the paper that reports this interaction (PubMedID 30258100)
32

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		SPDL1	USP45
Description		spindle apparatus coiled-coil protein 1	ubiquitin specific peptidase 45
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Enzyme Binding Kinetochore Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Chromosome Alignment Mitotic Spindle Assembly Checkpoint Signaling Cell Migration Protein Localization To Kinetochore Cell Division	Neural Retina Development DNA Repair Proteolysis Cell Migration Protein Deubiquitination Photoreceptor Cell Maintenance Global Genome Nucleotide-excision Repair
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Bipolar disorder x sex interaction ( 34099189)	Erectile dysfunction ( 30297428) Pursuit maintenance gain ( 29064472)
Interacting Genes		10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45	8 interacting genes: BMPR1B ERCC1 MYC SMAD1 SMURF1 SPDL1 TGFBR1 UBC
Entrez ID		54908	85015
HPRD ID		08623	11667
Ensembl ID		ENSG00000040275	ENSG00000123552
Uniprot IDs		Q96EA4	D6RBV3 Q70EL2
PDB IDs		8ARF
Enriched GO Terms of Interacting Partners?			I-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cartilage Development BMP Signaling Pathway Ubiquitin Protein Ligase Binding Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Cartilage Development Positive Regulation Of Developmental Process Regulation Of Chromosome Organization Negative Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Regulation Of Cellular Component Organization Cell Population Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Osteoblast Differentiation Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Cellular Developmental Process Positive Regulation Of DNA-templated Transcription Regulation Of Chondrocyte Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Bone Development Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Intracellular Iron Ion Homeostasis Positive Regulation Of MiRNA Transcription Positive Regulation Of Cell Projection Organization Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Engulfment Of Target By Autophagosome Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Chromosome Organization Regulation Of Apoptotic Signaling Pathway Pattern Specification Process
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