CA8 and RAB34

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		CA8	RAB34
Description		carbonic anhydrase 8	RAB34, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Golgi Apparatus Golgi Stack Centrosome Centriole Cytoskeleton Cilium Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Golgi Cisterna Ruffle Membrane Cell Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Calcium-mediated Signaling	Protein Transport Antigen Processing And Presentation Cell Projection Organization Lysosome Localization Golgi To Plasma Membrane Protein Transport Macropinocytosis Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Cytosolic Ciliogenesis Protein Localization To Plasma Membrane Phagosome Maturation Phagosome-lysosome Fusion
Pathways			RAB geranylgeranylation
Drugs		Zonisamide
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) High myopia ( 33830181) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 29483656 28991256 30285260 25056061) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Urate levels in lean individuals ( 25811787)
Interacting Genes		14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3	9 interacting genes: CA8 RABGAP1L RALA REP15 RILP SMAD1 SMAD2 SMAD4 TGFBR1
Entrez ID		767	83871
HPRD ID		00266	06701
Ensembl ID		ENSG00000178538	ENSG00000109113
Uniprot IDs		P35219	B4DNC0 E7ES60 P0DI83 Q96PJ7 Q9BZG1
PDB IDs		2W2J
Enriched GO Terms of Interacting Partners?			I-SMAD Binding SMAD Protein Complex Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Homomeric SMAD Protein Complex Activin Receptor Signaling Pathway Activin Responsive Factor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Trophoblast Cell Migration Response To Transforming Growth Factor Beta Roof Of Mouth Development Ubiquitin Protein Ligase Binding Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Response To Growth Factor Co-SMAD Binding Primary MiRNA Processing Secondary Palate Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Cardiac Conduction System Development Pattern Specification Process Ameboidal-type Cell Migration Regulation Of Extracellular Matrix Assembly Anterior/posterior Pattern Specification Response To Cholesterol R-SMAD Binding Positive Regulation Of Extracellular Matrix Organization Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Filopodium Assembly Embryonic Cranial Skeleton Morphogenesis Embryonic Axis Specification Endoderm Development MiRNA Processing Tube Development Neuron Fate Commitment Ventricular Septum Morphogenesis Ureteric Bud Development Transcription Regulator Complex Enzyme-linked Receptor Protein Signaling Pathway Establishment Of Protein Localization In Utero Embryonic Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Differentiation
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