CA8 and MAGED1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		CA8	MAGED1
Description		carbonic anhydrase 8	MAGE family member D1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromatin Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Calcium-mediated Signaling	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Protein Localization To Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Signaling Pathway
Pathways			NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand
Drugs		Zonisamide
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) High myopia ( 33830181) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 29483656 28991256 30285260 25056061) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Bell's palsy ( 33602968)
Interacting Genes		14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3	128 interacting genes: AGRN AKAP9 ARHGEF16 ARID5A ARNT2 BAG3 BAG4 BARD1 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CAPN7 CCDC120 CCDC33 CDC23 CERCAM CFAP206 CHERP DAB1 DAZAP2 DDX6 DLX4 DLX5 DMRT2 EIF3J EIF4E2 EP300 ERCC3 FAM83A FOXD2 FOXH1 FOXI1 FXR1 FXR2 GATA5 GLRA1 GLYCTK GPANK1 GPR135 GRAP2 HEMK1 HGS HIVEP1 HNRNPH1 HNRNPLL HOXC9 HSF2BP HUNK KPNA2 KPNA6 KRTAP19-5 KRTAP6-1 KRTAP6-3 LARP4B LENG8 LONRF1 MAPK1IP1L MAPK3 MDFI MEOX2 MGAT5B MKRN3 MPC1 MSX2 NAF1 NGFR NOTCH1 NOTO NPAS4 NUMBL PHF1 PITX1 PJA1 PJA2 PLK1 PNMA5 POM121 PRKAB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMF1 RAMAC RBFOX1 RBFOX2 RBM23 RBPMS RBPMS2 RFX1 RHOXF2 RNF6 RNF8 ROR2 RUSC1 RXFP4 SIM2 SIRT7 SMAP2 SMN1 SMN2 SNRPC SOX10 SOX5 TBX6 TFG TIAL1 TLX3 TRAF4 TRIM28 TSGA10IP TTC23 TTC32 TUBA4A UNC5A VASP VENTX XIAP YTHDF1 ZFYVE26 ZIC1 ZNF488 ZNF688
Entrez ID		767	9500
HPRD ID		00266	02202
Ensembl ID		ENSG00000178538	ENSG00000179222
Uniprot IDs		P35219	Q9Y5V3
PDB IDs		2W2J
Enriched GO Terms of Interacting Partners?			Regulation Of RNA Metabolic Process Cytoplasmic Stress Granule Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleic Acid Binding Nervous System Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Pattern Specification Process Embryonic Morphogenesis MRNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Negative Regulation Of RNA Metabolic Process Cytoplasmic Ribonucleoprotein Granule Nuclear Androgen Receptor Binding RNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Viral Penetration Into Host Nucleus Regulation Of RNA Splicing Transcription Regulator Complex
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