CA8 and LRCH4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CA8	LRCH4
Gene Name		carbonic anhydrase VIII	leucine-rich repeats and calponin homology (CH) domain containing 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	PML Body
	Molecular Function	Carbonate Dehydratase Activity Zinc Ion Binding	Protein Binding
	Biological Process	One-carbon Metabolic Process Phosphatidylinositol-mediated Signaling	Nervous System Development
Pathways
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661) Response to amphetamines ( 22952603)
Protein-Protein Interactions		9 interactors: CRX GGA2 HSD17B14 ITPR1 LNX1 LRCH4 MAGED1 SPDL1 TBX3	9 interactors: CA8 KRT40 KRTAP10-7 KRTAP10-8 MDFI NOTCH2NL RBBP6 RTN4 SIN3A
Entrez ID		767	4034
HPRD ID		00266	10062
Ensembl ID			ENSG00000077454
Uniprot IDs		P35219	O75427
PDB IDs		2W2J
Enriched GO Terms of Interacting Partners?		Atrioventricular Bundle Cell Differentiation Follicle-stimulating Hormone Secretion Positive Regulation Of Photoreceptor Cell Differentiation	Negative Regulation Of DNA Binding In Utero Embryonic Development Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding Negative Regulation Of Binding Response To Methylglyoxal Negative Regulation Of Histone H3-K27 Acetylation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Chromatin Silencing Regulation Of Protein Localization To Nucleus Multicellular Organismal Development Regulation Of Binding Endoplasmic Reticulum Tubular Network Organization Embryo Development
Tagcloud ?		a8344g anhydrase ataxia autophagic carbonic cerebellar cybrids distinctive encephalomyopathy exhibiting fibres gait harbouring inherited lc3 lifelong maternally merrf mtdna muscular myoclonus phospho ragged retardation staurosporine sts viii waddles wdl
Tagcloud (Difference) ?		a8344g anhydrase ataxia autophagic carbonic cerebellar cybrids distinctive encephalomyopathy exhibiting fibres gait harbouring inherited lc3 lifelong maternally merrf mtdna muscular myoclonus phospho ragged retardation staurosporine sts viii waddles wdl
Tagcloud (Intersection) ?