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ZFP36 and EXOSC6
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
ZFP36
EXOSC6
Gene Name
ZFP36 ring finger protein
exosome component 6
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Exosome (RNase Complex)
Nucleolus
Cytosol
Molecular Function
DNA Binding
Single-stranded RNA Binding
MRNA Binding
Protein Binding
AU-rich Element Binding
Enzyme Binding
Protein Kinase Binding
C-C Chemokine Binding
MRNA 3'-UTR AU-rich Region Binding
Poly(A) RNA Binding
Metal Ion Binding
14-3-3 Protein Binding
Exoribonuclease Activity
Poly(A) RNA Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Poly(A) Tail Shortening
MRNA Catabolic Process
Gene Expression
Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Translation Involved In Gene Silencing By MiRNA
Intracellular Signal Transduction
Response To Starvation
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Inflammatory Response
RNA Destabilization
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
3'-UTR-mediated MRNA Stabilization
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Isotype Switching
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
Tristetraprolin (TTP) destabilizes mRNA
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
22 interactors:
APP
CCDC85B
CDK6
DCP1B
DHX36
DNAJB1
EDC3
EXOSC6
EXOSC8
HMGB1
HOXC9
MAPK1
MAPKAPK2
NCL
NUP214
SFN
UPF2
XRN1
YWHAB
YWHAG
YWHAH
ZDHHC17
35 interactors:
C1QBP
CHPF
DCP1B
DIS3
DNAJC30
EIF3I
ESRRA
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC7
EXOSC8
EXOSC9
GSE1
LSM1
LSM7
LSM8
MAN2C1
MIF4GD
MOCS3
MPP6
MRPL4
MRPS18B
NDUFA13
NUDT21
PSMB1
RAB3GAP2
SKIV2L2
SRSF3
TUFM
UPF2
XRN1
ZFP36
Entrez ID
7538
118460
HPRD ID
01835
12107
Ensembl ID
ENSG00000128016
ENSG00000223496
Uniprot IDs
M0QY76
P26651
Q5RKV6
PDB IDs
4J8S
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
MRNA Catabolic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
RNA Catabolic Process
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Aromatic Compound Catabolic Process
Gene Expression
Positive Regulation Of Mitochondrion Organization
MRNA Metabolic Process
RNA Metabolic Process
Regulation Of Mitochondrion Organization
Regulation Of Cellular Response To Heat
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Catabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
System Development
Apoptotic Process
Cellular Nitrogen Compound Metabolic Process
Programmed Cell Death
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Organelle Organization
Cell Death
Death
Cellular Metabolic Process
Cellular Response To Heat
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Intracellular Transport
Regulation Of Protein Kinase Activity
Developmental Process
Nitrogen Compound Metabolic Process
Multicellular Organismal Development
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Transport
Innate Immune Response
Anatomical Structure Development
Positive Regulation Of Signal Transduction
Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Catabolic Process
Regulation Of Organelle Organization
Regulation Of Catalytic Activity
Response To Heat
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Metabolic Process
MRNA Catabolic Process
RNA Catabolic Process
RRNA Metabolic Process
Aromatic Compound Catabolic Process
Ribosome Biogenesis
RRNA Processing
Ribonucleoprotein Complex Biogenesis
Gene Expression
Cellular Macromolecule Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
NcRNA Metabolic Process
Nuclear MRNA Surveillance
RNA Metabolic Process
RNA Surveillance
RRNA Catabolic Process
Maturation Of 5.8S RRNA
RNA Phosphodiester Bond Hydrolysis
Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Catabolic Process
Nucleobase-containing Compound Metabolic Process
Histone MRNA Catabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Processing
Cellular Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Histone MRNA Metabolic Process
MRNA Processing
RNA Splicing
Metabolic Process
RNA 3'-end Processing
RNA Splicing, Via Transesterification Reactions
RNA Localization
DNA Deamination
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Intracellular MRNA Localization
Mitochondrial Translational Elongation
MRNA 3'-end Processing
Mitochondrion Organization
Mitochondrial Translation
MRNA Splicing, Via Spliceosome
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Tagcloud
?
annotation
bub
california
cruz
databases
david
deterioration
downloaded
exploring
geo
gse27567
h17
hub
inheritance
mendelian
networks
omim
omnibus
ranked
santa
topological
visualization
xpc
xrcc4
xrcc5
ybx1
yy1
zfhx3
zmat3
Tagcloud (Difference)
?
annotation
bub
california
cruz
databases
david
deterioration
downloaded
exploring
geo
gse27567
h17
hub
inheritance
mendelian
networks
omim
omnibus
ranked
santa
topological
visualization
xpc
xrcc4
xrcc5
ybx1
yy1
zfhx3
zmat3
Tagcloud (Intersection)
?