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ZFP36 and EXOSC8
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
ZFP36
EXOSC8
Gene Name
ZFP36 ring finger protein
exosome component 8
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Molecular Function
DNA Binding
Single-stranded RNA Binding
MRNA Binding
Protein Binding
AU-rich Element Binding
Enzyme Binding
Protein Kinase Binding
C-C Chemokine Binding
MRNA 3'-UTR AU-rich Region Binding
Poly(A) RNA Binding
Metal Ion Binding
14-3-3 Protein Binding
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Poly(A) Tail Shortening
MRNA Catabolic Process
Gene Expression
Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Translation Involved In Gene Silencing By MiRNA
Intracellular Signal Transduction
Response To Starvation
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Inflammatory Response
RNA Destabilization
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
3'-UTR-mediated MRNA Stabilization
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Biological_process
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
Tristetraprolin (TTP) destabilizes mRNA
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
22 interactors:
APP
CCDC85B
CDK6
DCP1B
DHX36
DNAJB1
EDC3
EXOSC6
EXOSC8
HMGB1
HOXC9
MAPK1
MAPKAPK2
NCL
NUP214
SFN
UPF2
XRN1
YWHAB
YWHAG
YWHAH
ZDHHC17
42 interactors:
AEN
ATF2
COL23A1
COX5A
CRMP1
CWC22
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM90A1
FHOD1
FOXN3
FRG1
LSM1
LSM7
MKRN1
MORN4
MPP6
OTUD4
RASSF1
REL
RPP14
SKIV2L2
SNRPC
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP6
XRN1
XRN2
ZFP36
Entrez ID
7538
11340
HPRD ID
01835
09351
Ensembl ID
ENSG00000128016
ENSG00000120699
Uniprot IDs
M0QY76
P26651
Q96B26
PDB IDs
4J8S
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
MRNA Catabolic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
RNA Catabolic Process
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Aromatic Compound Catabolic Process
Gene Expression
Positive Regulation Of Mitochondrion Organization
MRNA Metabolic Process
RNA Metabolic Process
Regulation Of Mitochondrion Organization
Regulation Of Cellular Response To Heat
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Catabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
System Development
Apoptotic Process
Cellular Nitrogen Compound Metabolic Process
Programmed Cell Death
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Organelle Organization
Cell Death
Death
Cellular Metabolic Process
Cellular Response To Heat
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Intracellular Transport
Regulation Of Protein Kinase Activity
Developmental Process
Nitrogen Compound Metabolic Process
Multicellular Organismal Development
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Transport
Innate Immune Response
Anatomical Structure Development
Positive Regulation Of Signal Transduction
Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Catabolic Process
Regulation Of Organelle Organization
Regulation Of Catalytic Activity
Response To Heat
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Ribosome Biogenesis
Aromatic Compound Catabolic Process
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
RNA Metabolic Process
Cellular Macromolecule Catabolic Process
NcRNA Metabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis
RRNA Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Maturation Of 5.8S RRNA
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
DNA Deamination
Histone MRNA Catabolic Process
RNA Processing
Cellular Metabolic Process
Histone MRNA Metabolic Process
MRNA Processing
Intracellular MRNA Localization
Metabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
DNA Modification
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RNA Splicing
SnoRNA Metabolic Process
RNA Splicing, Via Transesterification Reactions
Tagcloud
?
annotation
bub
california
cruz
databases
david
deterioration
downloaded
exploring
geo
gse27567
h17
hub
inheritance
mendelian
networks
omim
omnibus
ranked
santa
topological
visualization
xpc
xrcc4
xrcc5
ybx1
yy1
zfhx3
zmat3
Tagcloud (Difference)
?
annotation
bub
california
cruz
databases
david
deterioration
downloaded
exploring
geo
gse27567
h17
hub
inheritance
mendelian
networks
omim
omnibus
ranked
santa
topological
visualization
xpc
xrcc4
xrcc5
ybx1
yy1
zfhx3
zmat3
Tagcloud (Intersection)
?