ZFP36 and DHX36

Number of citations of the paper that reports this interaction (PMID 21964062)
3

Data Source:
BioGRID (two hybrid)

		ZFP36	DHX36
Gene Name		ZFP36 ring finger protein	DEAH (Asp-Glu-Ala-His) box polypeptide 36
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule	Chromosome, Telomeric Region Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding AU-rich Element Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding MRNA 3'-UTR AU-rich Region Binding Poly(A) RNA Binding Metal Ion Binding 14-3-3 Protein Binding	Core Promoter Binding G-quadruplex RNA Binding Double-stranded RNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding G-quadruplex DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Gene Expression Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Intracellular Signal Transduction Response To Starvation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Ossification Transcription, DNA-templated RNA Processing Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Tristetraprolin (TTP) destabilizes mRNA	DEx/H-box helicases activate type I IFN and inflammatory cytokines production RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 7/8 (TLR7/8) Cascade Cytosolic sensors of pathogen-associated DNA MyD88 dependent cascade initiated on endosome TRAF6 mediated IRF7 activation Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP CCDC85B CDK6 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 SFN UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17	3 interactors: IL7R TLR1 ZFP36
Entrez ID		7538	170506
HPRD ID		01835	09918
Ensembl ID		ENSG00000128016	ENSG00000174953
Uniprot IDs		M0QY76 P26651	Q9H2U1
PDB IDs		4J8S
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway MRNA Catabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Aromatic Compound Catabolic Process Gene Expression Positive Regulation Of Mitochondrion Organization MRNA Metabolic Process RNA Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Cellular Response To Heat Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process System Development Apoptotic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Cell Death Death Cellular Metabolic Process Cellular Response To Heat Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Protein Kinase Activity Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Innate Immune Response Anatomical Structure Development Positive Regulation Of Signal Transduction Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process Regulation Of Organelle Organization Regulation Of Catalytic Activity Response To Heat Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death	Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 1 Signaling Pathway Regulation Of Immune System Process Interleukin-7-mediated Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Immune System Process Detection Of Bacterial Lipoprotein Negative Regulation Of Translation Involved In Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Leukocyte Activation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Cellular Response To Bacterial Lipopeptide RNA Destabilization Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lymph Node Development Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of MRNA 3'-end Processing Regulation Of Interleukin-6 Biosynthetic Process Cell Activation Detection Of Bacterium Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Stabilization Detection Of Biotic Stimulus Macrophage Activation Regulation Of Immune Response Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immune System Process Gene Silencing By MiRNA Negative Regulation Of Adaptive Immune Response Posttranscriptional Gene Silencing B Cell Proliferation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Stability Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Stability Immunoglobulin Production Gene Silencing By RNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process
Tagcloud ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 ybx1 yy1 zfhx3 zmat3	another antiviral atpase avsg box defect defense dexd dsrna facilitate facilitates forming granule helicase ifn inducible initiate interferon ko mef pkr recognition rig rlr rna sensor stranded summary viruses
Tagcloud (Difference) ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 ybx1 yy1 zfhx3 zmat3	another antiviral atpase avsg box defect defense dexd dsrna facilitate facilitates forming granule helicase ifn inducible initiate interferon ko mef pkr recognition rig rlr rna sensor stranded summary viruses
Tagcloud (Intersection) ?