SF1 and EFTUD2

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		SF1	EFTUD2
Gene Name		splicing factor 1	elongation factor Tu GTP binding domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome	Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Membrane Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Transcription Corepressor Activity RNA Binding Zinc Ion Binding Poly(A) RNA Binding	GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated Male Sex Determination Leydig Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		45 interactors: APBB1 ATXN1 BCAS2 BCL2 CIAO1 DDX17 EFTUD2 ESR1 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MKRN3 NFKB1 PLSCR1 PNRC2 PRKG1 PRPF40A PSMA3 RBM10 RBM17 RBM4 RBM7 RBPMS SF3A1 SF3B4 TAF15 TCERG1 TRIM23 TRIM69 U2AF2 WBP4 WDR77 WDR83 WWP2 ZNF461	16 interactors: ARPC3 CYFIP1 GOLM1 GSK3B HINFP HSPB1 LSM8 PIN1 PRPF6 PRPF8 SF1 SF3B3 SF3B4 SNRNP40 SREK1 WBP4
Entrez ID		7536	9343
HPRD ID		03306	04869
Ensembl ID		ENSG00000168066	ENSG00000108883
Uniprot IDs		Q15637	B3KX19 B4DMC0 K7EJ81 Q15029
PDB IDs		1K1G 1OPI 2M09 2M0G 4FXW 4FXX
Enriched GO Terms of Interacting Partners?		RNA Processing RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Metabolic Process Transcription, DNA-templated Regulation Of RNA Splicing RNA Biosynthetic Process Cellular Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Cellular Macromolecule Biosynthetic Process Response To Virus Positive Regulation Of Cellular Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Biosynthetic Process Defense Response To Virus Regulation Of MRNA Splicing, Via Spliceosome Protein Polyubiquitination Regulation Of Viral Genome Replication Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Positive Regulation Of Transcription, DNA-templated Regulation Of MRNA Processing Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Activation Apoptotic Process Response To Other Organism	RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Processing Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spliceosomal Tri-snRNP Complex Assembly Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Cellular Metabolic Process Spliceosomal Complex Assembly Ribonucleoprotein Complex Biogenesis Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Organelle Organization Hypermethylation Of CpG Island Primary Sex Determination Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Positive Regulation Of Cellular Biosynthetic Process MRNA 3'-splice Site Recognition Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Interleukin-3 Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Female Gonad Development Positive Regulation Of Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Neuron Maturation Axonogenesis Negative Regulation Of MAPK Cascade Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Microtubule Positive Regulation Of Actin Nucleation Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Protein Complex Assembly
Tagcloud ?		aaggtcagaaat aromatase belong br clones coup decided differently dnase ear encode err footprinting hybrid mobility ovary p120e4f promoters s1 shorter silencer situated sk specimen superfamily tf1 variant ws3tf	3k36me3 antagonizing arranged bromo bs69 called chromatin connects decorated depends h3k36me3 identifies intron ir modalities phd pwwp reader recognizes remarkably retention reveals snrnp spliceosome splicing tandemly trimethylation u5 zmynd11
Tagcloud (Difference) ?		aaggtcagaaat aromatase belong br clones coup decided differently dnase ear encode err footprinting hybrid mobility ovary p120e4f promoters s1 shorter silencer situated sk specimen superfamily tf1 variant ws3tf	3k36me3 antagonizing arranged bromo bs69 called chromatin connects decorated depends h3k36me3 identifies intron ir modalities phd pwwp reader recognizes remarkably retention reveals snrnp spliceosome splicing tandemly trimethylation u5 zmynd11
Tagcloud (Intersection) ?