SF1 and RBM10

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		SF1	RBM10
Description		splicing factor 1	RNA binding motif protein 10
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome U2AF Complex	Nucleus Nucleoplasm Nucleolus Nuclear Speck Protein-containing Complex
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding MiRNA Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Primary Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome MRNA Processing Negative Regulation Of Cell Population Proliferation RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Apoptotic Process Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Ribosomal Large Subunit Export From Nucleus
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs		Artenimol
Diseases			TARP syndrome
GWAS		Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)
Interacting Genes		90 interacting genes: ALG13 APBB1 APOBEC3C ATXN1 BAG4 BCAS2 BCL2 BUD31 CDC42 CEBPA CEP55 CPSF7 CTBP1 CTTN DCN DDX17 DMRTB1 DUX4L9 EWSR1 EXOSC1 EXOSC8 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IDH3A IL7R ILF3 ITCH KHDRBS2 KPNA1 KRT31 KRTAP26-1 LINC00632 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NEIL3 NFKB1 OGT OSTF1 PDAP1 PLSCR1 PRKG1 PRPF39 PRPF40A PRRC2B PSMA3 PUF60 PUS7 RBFOX2 RBM10 RBM17 RBM4 RBM7 RBMX RBPMS RPA2 RSPH1 SEC23A SF3B1 SF3B4 SFPQ SNRPA TAF15 TCERG1 TFIP11 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 USO1 WBP4 WDR77 WDR83 WWP2 YTHDF1 YTHDF3 ZNF461	73 interacting genes: AKAP9 ATN1 BAHD1 BEND7 CASK CBLL1 CCAR1 CEP70 CPSF7 CSNK2A1 DDX17 DDX5 FAM124A GTSE1 HNRNPH2 HNRNPK HNRNPLL IK KHDRBS2 KLF1 MAPRE2 MBD6 MDM2 MEOX2 MIR106B MIR107 MIR128-1 MIR21 MIR214 MIRLET7A1 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7G MIRLET7I NDEL1 NIN PATZ1 PCBP1 PRC1 PRCC PRDM14 PRR20A PTBP1 PTBP2 RBM12 RBM12B RBM14 RBM4 RBM7 RBMY1F RNF10 SF1 SF3A1 SF3B2 SF3B4 SLAIN1 SNRPA SNU13 SREK1 SRSF6 TBC1D22B THAP1 TLE5 U2AF1 UBQLN4 ZBTB24 ZFP64 ZNF275 ZNF317 ZNF408 ZNF473 ZNF526
Entrez ID		7536	8241
HPRD ID		03306	02095
Ensembl ID		ENSG00000168066	ENSG00000182872
Uniprot IDs		A0A7P0T9U7 A0A9L9PXE4 B4DX42 H7C561 Q15637	A0A0S2Z4W4 A0A0S2Z4X1 P98175
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX 7VH9 7VPX 8PXX	2LXI 2M2B 2MXV 2MXW 5ZSW 5ZSY
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process RNA Binding RNA Metabolic Process Nucleic Acid Binding Regulation Of RNA Splicing Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression MRNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Speck Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Identical Protein Binding Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Splicing	MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing Nucleic Acid Binding RNA Splicing Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Processing Post-transcriptional Gene Silencing Spliceosomal Complex MRNA Splicing, Via Spliceosome MRNA Base-pairing Post-transcriptional Repressor Activity RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome RNA Binding MRNA Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleoplasm Nuclear Speck Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Ribonucleoprotein Complex Pre-mRNA Binding MRNA 3'-UTR Binding Post-transcriptional Regulation Of Gene Expression U2-type Precatalytic Spliceosome Negative Regulation Of RNA Splicing Microtubule Nucleation
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