SF1 and DDX17

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SF1	DDX17
Gene Name		splicing factor 1	DEAD (Asp-Glu-Ala-Asp) box helicase 17
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome	Nucleus Nucleoplasm Nucleolus Membrane
	Molecular Function	Transcription Corepressor Activity RNA Binding Zinc Ion Binding Poly(A) RNA Binding	Transcription Coactivator Activity RNA Binding RNA Helicase Activity Protein Binding ATP Binding RNA-dependent ATPase Activity Estrogen Receptor Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated Male Sex Determination Leydig Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription	Transcription, DNA-templated RNA Processing Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		45 interactors: APBB1 ATXN1 BCAS2 BCL2 CIAO1 DDX17 EFTUD2 ESR1 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MKRN3 NFKB1 PLSCR1 PNRC2 PRKG1 PRPF40A PSMA3 RBM10 RBM17 RBM4 RBM7 RBPMS SF3A1 SF3B4 TAF15 TCERG1 TRIM23 TRIM69 U2AF2 WBP4 WDR77 WDR83 WWP2 ZNF461	28 interactors: APBB1 APP BYSL CREBBP CSNK2A1 DDX5 ESR2 FBL GRB2 HDAC1 HNRNPH3 HNRNPK LNX1 NCOA1 NCOA2 NCOA3 PIN1 RBM15 RBM4 SF1 SF3B4 SNRNP70 SORBS3 SRA1 SREK1 U2AF2 WBP11 YWHAG
Entrez ID		7536	10521
HPRD ID		03306	10532
Ensembl ID		ENSG00000168066	ENSG00000100201
Uniprot IDs		Q15637	Q59F66 Q92841
PDB IDs		1K1G 1OPI 2M09 2M0G 4FXW 4FXX
Enriched GO Terms of Interacting Partners?		RNA Processing RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Metabolic Process Transcription, DNA-templated Regulation Of RNA Splicing RNA Biosynthetic Process Cellular Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Cellular Macromolecule Biosynthetic Process Response To Virus Positive Regulation Of Cellular Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Biosynthetic Process Defense Response To Virus Regulation Of MRNA Splicing, Via Spliceosome Protein Polyubiquitination Regulation Of Viral Genome Replication Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Positive Regulation Of Transcription, DNA-templated Regulation Of MRNA Processing Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Activation Apoptotic Process Response To Other Organism	RNA Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing Gene Expression Nucleobase-containing Compound Metabolic Process Rhythmic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of RNA Splicing Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Regulation Of Receptor Activity Histone Modification Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Acetylation Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Cell Differentiation Regulation Of Androgen Receptor Signaling Pathway Labyrinthine Layer Morphogenesis Developmental Process Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Chromatin Modification Embryonic Placenta Morphogenesis Transcription From RNA Polymerase II Promoter
Tagcloud ?		aaggtcagaaat aromatase belong br clones coup decided differently dnase ear encode err footprinting hybrid mobility ovary p120e4f promoters s1 shorter silencer situated sk specimen superfamily tf1 variant ws3tf	34a 3a adding auf1 contexts cpeb4 dimension doxorubicin focusing hnrnpd indirect keeps master mcf7 modulated nutlin polysomal preferentially searched srsf1 subpolysomal tardbp transcriptome translational translatome uncoupled uncoupling variations ybx1
Tagcloud (Difference) ?		aaggtcagaaat aromatase belong br clones coup decided differently dnase ear encode err footprinting hybrid mobility ovary p120e4f promoters s1 shorter silencer situated sk specimen superfamily tf1 variant ws3tf	34a 3a adding auf1 contexts cpeb4 dimension doxorubicin focusing hnrnpd indirect keeps master mcf7 modulated nutlin polysomal preferentially searched srsf1 subpolysomal tardbp transcriptome translational translatome uncoupled uncoupling variations ybx1
Tagcloud (Intersection) ?